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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
Hypoxia-inducible factor 1 (HIF-1) is found in mammalian cells cultured under reduced O2 tension and is necessary for transcriptional activation mediated by the erythropoietin gene enhancer inExpand
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
TLDR
A functionally tripartite, 50-nt hypoxia-inducible enhancer which binds several nuclear factors, one of which is induced by Hypoxia via de novo protein synthesis. Expand
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1 activity is also induced by hypoxia in non-erythropoietin-producing cells,Expand
RFLP mapping of genes conferring complete and partial resistance to blast in a durably resistant rice cultivar.
TLDR
This study illustrates the usefulness of RI lines for mapping a complex trait such as blast resistance and suggests that durable resistance in the traditional variety, Moroberekan, involves a complex of genes associated with both partial and complete resistance. Expand
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
  • G. Wang, G. Semenza
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 May 1993
TLDR
It is demonstrated that Hif-1 DNA binding activity is also induced by hypoxia in a variety of mammalian cell lines in which the EPO gene is not transcribed, providing evidence that HIF-1 and its recognition sequence are common components of a general mammalian cellular response to Hypoxia. Expand
Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction.
TLDR
Treatment of Hep3B cells with desferrioxamine (DFX) induced HIF-1 activity and EPO RNA expression with kinetics similar to the induction of Hif-1 by hypoxia or cobalt chloride, suggesting the existence of a common Hypoxia signal-transduction pathway leading to HIF -1 induction in different cell types. Expand
Characterizing rice lesion mimic mutants and identifying a mutant with broad-spectrum resistance to rice blast and bacterial blight.
  • Z. Yin, J. Chen, +4 authors G. Wang
  • Biology, Medicine
  • Molecular plant-microbe interactions : MPMI
  • 1 August 2000
TLDR
The results suggest that some lesion mimic mutations in rice may be involved in disease resistance, and cloning of these genes may provide a clue to developing broad-spectrum resistance to diverse pathogens. Expand
Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.
  • G. Wang, G. Semenza
  • Biology, Medicine
  • The Journal of biological chemistry
  • 15 October 1993
TLDR
It is demonstrated that induction of both Hif-1 and erythropoietin RNA is inhibited by the protein kinase inhibitor 2-aminopurine, consistent with the proposed function of HIF-1 as a physiologic regulator of gene expression that responds to changes in cellular oxygen tension. Expand
Evolution of the rice Xa21 disease resistance gene family.
TLDR
A model for amplification and diversification of the Xa21 gene family is presented and two distinct classes of genes are revealed, including a receptor kinase-like open reading frame and truncated open reading frames of the predicted receptor Kinase. Expand
Rice (Oryza sativa) centromeric regions consist of complex DNA.
TLDR
Fiber-fluorescence in situ hybridization analysis revealed that the RCS2 family is organized into long uninterrupted arrays and resembles previously reported tandem repeats located in the centromeres of human and Arabidopsis thaliana chromosomes. Expand
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