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Mutant Huntingtin Downregulates Myelin Regulatory Factor-Mediated Myelin Gene Expression and Affects Mature Oligodendrocytes
Growing evidence indicates that non-neuronal mutant huntingtin toxicity plays an important role in Huntington's disease (HD); however, whether and how mutant huntingtin affects oligodendrocytes,Expand
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The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18.
The rhizosphere microbe Pseudomonas aeruginosa M18 shows strong antifungal activities, mainly due to the biosynthesis of antibiotics like pyoluteorin (Plt) and phenazine-1-carboxylic acid (PCA). TheExpand
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Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis
Significance Because of the toxicity gain of expanded polyglutamine (polyQ) repeats, many studies have used RNAi and other approaches to inactivate the mutant HTT gene in Huntington’s disease.Expand
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Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain
Parkinson's disease (PD) is an age-dependent neurodegenerative disease that often occurs in those over age 60. Although rodents and small animals have been used widely to model PD and investigate itsExpand
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Transcriptional Activation of Pyoluteorin Operon Mediated by the LysR-Type Regulator PltR Bound at a 22 bp lys Box in Pseudomonas aeruginosa M18
Pseudomonas aeruginosa M18, a rhizosphere-isolated bacterial strain showing strong antifungal activity, can produce secondary metabolites such as phenazine-1-carboxylic acid and pyoluteorin (Plt).Expand
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Hybrid graphene/Au activatable theranostic agent for multimodalities imaging guided enhanced photothermal therapy.
Photothermal therapy (PTT) has been increasingly investigated. However, there are still challenges in strategies that can further enhance photoconversion efficiency and improve photothermal tumorExpand
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Nanotubes-Embedded Indocyanine Green-Hyaluronic Acid Nanoparticles for Photoacoustic-Imaging-Guided Phototherapy.
  • G. Wang, F. Zhang, +4 authors L. Zhu
  • Medicine, Materials Science
  • ACS applied materials & interfaces
  • 19 February 2016
Phototherapy is a light-triggered treatment for tumor ablation and growth inhibition via photodynamic therapy (PDT) and photothermal therapy (PTT). Despite extensive studies in this area, a majorExpand
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Species-dependent neuropathology in transgenic SOD1 pigs
Mutations in the human copper/zinc superoxide dismutase 1 (hSOD1) gene cause familial amyotrophic lateral sclerosis (ALS). It remains unknown whether large animal models of ALS mimic moreExpand
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Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance andExpand
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Impaired amyloid β-degrading enzymes in brain of streptozotocin-induced diabetic rats
Enzymes that degrade the amyloid β-peptide (Aβ) are important regulators of cerebral Aβ levels. High level of Aβ was found in the brain of diabetic patients and diabetic animals. Aim of the study wasExpand
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