• Publications
  • Influence
Opioids and alcoholism
Although far from conclusive, evidence implicating the endogenous opioid system in the development and maintenance of alcoholism is growing. Currently available data suggest that ethanol increasesExpand
  • 234
  • 16
Stress and the HPA axis: role of glucocorticoids in alcohol dependence.
Stress has long been suggested to be an important correlate of uncontrolled drinking and relapse. An important hormonal response system to stress—the hypothalamic–pituitary–adrenal (HPA) axis—may beExpand
  • 212
  • 15
Relationship between Cortisol Responses to Stress and Personality
Although there is growing evidence of links between the cortisol stress response and personality, the nature of the relationships and the underlying mechanisms require further clarification. TheExpand
  • 185
  • 13
Associations of salivary cortisol with cognitive function in the Baltimore memory study.
CONTEXT The stress responses of the hypothalamic-pituitary-adrenal axis can produce adverse effects on the brain. Previous studies have concluded that an elevated level of cortisol is a risk factorExpand
  • 213
  • 11
The cAMP–Protein Kinase A Signal Transduction Pathway Modulates Ethanol Consumption and Sedative Effects of Ethanol
Ethanol and other drugs of abuse modulate cAMP–PKA signaling within the mesolimbic reward pathway. To understand the role of the cAMP–PKA signal transduction in mediating the effects of ethanol, weExpand
  • 139
  • 10
Sex Differences in Striatal Dopamine Release in Healthy Adults
BACKGROUND Sex differences in addictive disorders have been described. Preclinical studies have implicated the striatal dopamine system in these differences, but human studies have yet toExpand
  • 267
  • 9
Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice.
There is evidence for hypercortisolemia playing a role in the generation of psychiatric symptoms and for epigenetic variation within hypothalamic-pituitary-adrenal (HPA) axis genes mediatingExpand
  • 208
  • 9
Genetic association of FKBP5 and CRHR1 with cortisol response to acute psychosocial stress in healthy adults
RationaleChronic dysregulation of hypothalamus–pituitary–adrenal (HPA) axis activity is related to several neuropsychiatric disorders. Studies suggest that cortisol response to stress has a strongExpand
  • 90
  • 9
Reliability of hypothalamic–pituitary–adrenal axis assessment methods for use in population-based studies
Population-based studies have been hampered in exploring hypothalamic–pituitary–adrenal axis (HPA) activity as a potential explanatory link between stress-related and metabolic disorders due to theirExpand
  • 71
  • 9
Family history of alcoholism and hypothalamic opioidergic activity.
BACKGROUND This study was designed to assess whether nonalcoholic offspring from families with a high density of alcohol-dependent individuals have altered endogenous central nervous system opioidExpand
  • 124
  • 8