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Functional and structural characterization of the eosinophil P-selectin ligand.
- F. Symon, M. Lawrence, M. L. Williamson, G. Walsh, S. Watson, A. Wardlaw
- Biology, MedicineJournal of immunology
- 15 August 1996
The increased binding of eosinophils, compared with neutrophils, to P- selectin in both an ex-vivo and in vitro assay suggests that P-selectin may have a role directing the specific migration of eOSinophil in diseases such as asthma.
Nasal epithelial cells as surrogates for bronchial epithelial cells in airway inflammation studies.
- C. McDougall, M. Blaylock, J. Douglas, R. Brooker, P. Helms, G. Walsh
- Medicine, BiologyAmerican journal of respiratory cell and…
- 15 May 2008
Despite differences in absolute mediator levels, the responses of nasal and bronchial epithelial cells to cytokine stimulation were similar, expression of relevant surface receptors was comparable, and there were significant correlations between nasal and Bronchial cell mediator release.
Integrin α4β7 mediates human eosinophil interaction with MAdCAM‐1, VCAM‐1 and fibronectin
It is confirmed that α4β1 is functionally active on unstimulated eosinophils and may have an important role in eos inophil localization in diseases such as asthma and inflammatory bowel disease.
Eosinophil Apoptosis and Clearance in Asthma
- G. Walsh
- Medicine, BiologyJournal of cell death
- 17 April 2013
New knowledge is updated of the mechanisms controlling eosinophil apoptosis and clearance, together with evidence implicating defects in apoptotic process and pro-inflammatory cell removal in asthma.
Eosinophil adhesion to nasal polyp endothelium is P-selectin-dependent
- F. Symon, G. Walsh, S. Watson, A. Wardlaw
- Biology, MedicineThe Journal of experimental medicine
- 1 July 1994
The importance of P- selectin in eosinophil adhesion to nasal polyp endothelium suggests that P-selectin antagonists may be effective at inhibiting eos inophil accumulation at sites of allergic inflammation.
Fc gamma and CD11/CD18 receptor expression on normal density and low density human eosinophils.
The findings emphasize the unique phenotype of the human eosinophil in terms of Fc gamma receptor expression, the similarity of the eosInophil and neutrophil with regard to the leucocyte integrins and that eos inophils of low density do not differ greatly from those of normal density in termsof receptor expression.
Initial cytokine exposure determines function of macrophages and renders them unresponsive to other cytokines.
The functional response of BMDMs to complex mixtures of cytokines was determined by the first cytokine to which they were exposed, which has obvious implications for Mphi function in vivo.
Ligation of CD69 induces apoptosis and cell death in human eosinophils cultured with granulocyte-macrophage colony-stimulating factor.
It is suggested that eosinophils cultured with GM-CSF can be induced to undergo apoptosis as a result of cell signalling mediated by perturbation of CD69, and may represent an important physiologic mechanism for eOSinophil removal in vivo.
Advances in the immunobiology of eosinophils and their role in disease.
- G. Walsh
- Medicine, BiologyCritical reviews in clinical laboratory sciences
- 1 October 1999
The current understanding of the role of the eosinophil in human disease and the immunobiology of this important proinflammatory cell is reviewed.
Corticosteroids, eosinophils and bronchial epithelial cells: new insights into the resolution of inflammation in asthma.
The role that steroids and membrane receptor ligation play in the induction of eosinophil apoptosis together with the mechanisms by which corticosteroids enhance the disposal of apoptotic eOSinophils by both professional and non-professional phagocytes are reviewed.