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Structure of a human common cold virus and functional relationship to other picornaviruses
We report the first atomic resolution structure of an animal virus, human rhinovirus 14. It is strikingly similar to known icosahedral plant RNA viruses. Four neutralizing immunogenic regions haveExpand
PredictProtein—an open resource for online prediction of protein structural and functional features
The goal has always been to develop a system optimized to meet the demands of experimentalists not highly experienced in bioinformatics, and the PredictProtein results are presented as both text and a series of intuitive, interactive and visually appealing figures. Expand
Quality control of protein models : directional atomic contact analysis
Branden & Jones state, in Nature: `Protein crystallography is an exacting trade, and the results may contain errors that are difficult to identify. It is the crystallographer's responsibility to makeExpand
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2.
The POU transcription factor Oct-4 is expressed specifically in the germ line, pluripotent cells of the pregastrulation embryo and stem cell lines derived from the early embryo. Osteopontin (OPN) isExpand
Prediction of protein conformational freedom from distance constraints
Applications to an IgG‐binding domain, an SH3 binding domain, HPr, calmodulin, and lysozyme are presented which illustrate the use of the method as a fast and simple way to predict structural variability in proteins. Expand
Rubredoxin reductase of Pseudomonas oleovorans. Structural relationship to other flavoprotein oxidoreductases based on one NAD and two FAD fingerprints.
This study shows that alkT encodes the 41 x 10(3) Mr rubredoxin reductase, on the basis of a comparison of the expected amino acid composition of AlkT and the previously established amino acids composition of the purified rubred toxin reduct enzyme. Expand
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating.
Two compounds are structurally related, antiviral compounds that inhibit the replication of rhino (common cold) viruses and related picornaviruses and prevent the pH-mediated uncoating of the viral RNA. Expand
Generic GPCR residue numbers - aligning topology maps while minding the gaps.
This work reviews the generic residue numbering schemes for each GPCR class, as well as a complementary structure-based scheme, and provides illustrative examples and G PCR database (GPCRDB) web tools to number any receptor sequence or structure. Expand
Synergism with the Coactivator OBF-1 (OCA-B, BOB-1) Is Mediated by a Specific POU Dimer Configuration
These findings provide a paradigm of how specific POU dimer assemblies can differentially recruit a coregulatory activity with distinct transcriptional readouts. Expand
Engineering an enzyme to resist boiling.
This work shows how a moderately stable enzyme (a thermolysin-like protease from Bacillus stearothermophilus, TLP-ste) can be made hyperstable by a limited number of mutations. Expand