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Comparative responses of three rat strains (DA/Han, Sprague-Dawley and Wistar) to treatment with environmental estrogens
The rat uterotrophic assay is a widely used screening test for the detection of estrogenic, endocrine-disrupting chemicals. Although much attention has been paid to identifying protocol variables and… Expand
Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats
- P. Diel, T. Hertrampf, J. Seibel, U. Laudenbach-Leschowsky, G. Vollmer
- Biology, Medicine
- The Journal of Steroid Biochemistry and Molecular…
- 1 December 2006
The knowledge about safety of phytoestrogens on proliferative endpoints in the endometrium is rather limited, particularly when low amounts of estrogens are present like in postmenopausal women.… Expand
In vitro estrogenic activity of two major compounds from the stem bark of Erythrina lysistemon (Fabaceae).
- Chantal Béatrice Magne Ndé, D. Njamen, +4 authors G. Vollmer
- Chemistry, Medicine
- European journal of pharmacology
- 15 January 2012
Plant-derived estrogen-like compounds, so called phytoestrogens, are given much attention due to their potential therapeutic use. In our previous work the ethylacetate extract of Erythrina lysistemon… Expand
Tools to evaluate estrogenic potency of dietary phytoestrogens:A consensus paper from the EU Thematic Network “Phytohealth” (QLKI-2002-2453)
Phytoestrogens are naturally occurring plantderived polyphenols with estrogenic potency. They are ubiquitous in diet and therefore, generally consumed. Among Europeans, the diet is rich in multiple… Expand
The prohormone 19-norandrostenedione displays selective androgen receptor modulator (SARM) like properties after subcutaneous administration.
One of the most frequently misused steroid precursors (prohormones) is 19-norandrostenedione (4-estrene-3,17-dione, NOR), which is, after oral administration, readily metabolised to nortestosterone,… Expand
Long-term detection of methyltestosterone (ab-) use by a yeast transactivation system
The routinely used analytical method for detecting the abuse of anabolic steroids only allows the detection of molecules with known analytical properties. In our supplementary approach to… Expand
Progesterone, as well as 17β-estradiol, is important for regulating AHR battery homoeostasis in the rat uterus
Abstract Several studies indicate that the aryl hydrocarbon receptor (AHR), which plays an important role in mediating the toxicity of many industrial chemicals, plays an important role in the… Expand
Increased bone remodelling around titanium implants coated with chondroitin sulfate in ovariectomized rats.
- J. Dudeck, S. Rehberg, +8 authors S. Rammelt
- Materials Science, Medicine
- Acta biomaterialia
- 1 June 2014
Coating titanium implants with artificial extracellular matrices based on collagen and chondroitin sulfate (CS) has been shown to enhance bone remodelling and de novo bone formation in vivo. The aim… Expand
A novel combined approach to detect androgenic activities with yeast based assays in Schizosaccharomyces pombe and Saccharomyces cerevisiae.
We describe the construction and validation of novel test systems for detecting androgenic activities using a combination of the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. By… Expand
Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α
The aryl hydrocarbon receptor (AHR) is known to mediate the cellular response to numerous xenobiotics including dioxin. Surprisingly AHR knockout mice provide evidence for the involvement of the AHR… Expand