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ETV4 collaborates with Wnt/β-catenin signaling to alter cell cycle activity and promote tumor aggressiveness in gastrointestinal stromal tumor
It is found that ETV4 levels were high in a subset of human GISTs and correlated with high mitotic rate and identified ETV 4 as a biomarker in human Gists. Expand
Gastric remnant cancer: A distinct entity or simply another proximal gastric cancer?
The purpose of this study was to compare outcomes following resection of gastric remnant (GRC) and conventional gastric cancer.
Macrophages and CD8+ T Cells Mediate the Antitumor Efficacy of Combined CD40 Ligation and Imatinib Therapy in Gastrointestinal Stromal Tumors
- Jennifer Q. Zhang, S. Zeng, +13 authors R. DeMatteo
- Cancer Immunology Research
- 21 February 2018
Ligation of CD40 using an agonistic antibody (anti-CD40) activated tumor-associated macrophages (TAMs) in vivo in a knock-in mouse model of GIST harboring a germline mutation in Kit exon 11, supporting the combination's use in patients with these tumors. Expand
Differential immune profiles distinguish the mutational subtypes of gastrointestinal stromal tumor.
- G. Vitiello, T. Bowler, +9 authors R. DeMatteo
- Biology, Medicine
- The Journal of clinical investigation
- 1 May 2019
Gastrointestinal stromal tumor (GIST) is the most common human sarcoma, frequently characterized by an oncogenic mutation in the KIT or platelet-derived growth factor receptor alpha (PDGFRA) genes.… Expand
Endovascular Treatment of Spontaneous Renal Artery Dissection After Failure of Medical Management
A 40-year-old man with a recently diagnosed SRAD was managed appropriately with therapeutic anticoagulation, yet presented with progression of his dissection and a new acute renal infarct, so a covered endovascular stent was used to successfully control dissection progression and prevent further renal compromise. Expand
Perihilar Cholangiocarcinoma: Number of Nodes Examined and Optimal Lymph Node Prognostic Scheme.
- F. Bagante, T. Tran, +24 authors T. Pawlik
- Journal of the American College of Surgeons
- 1 May 2016
Perihilar cholangiocarcinoma patients undergoing radical resection should ideally have at least 4 lymph nodes harvested to be accurately staged, and both lymph node ratio and LODDS outperformed compared with American Joint Committee on Cancer N stage among patients with ≥4 TNLE. Expand
The Role of the Microbiome in Immunologic Development and its Implication For Pancreatic Cancer Immunotherapy.
How microbe-induced immune activation promotes oncogenesis and modulation of the microbiome augments the anti-cancer immune response and enables successful immunotherapy against pancreatic cancer is reviewed. Expand
Utility of Prostate Cancer Screening in Kidney Transplant Candidates.
- G. Vitiello, B. Sayed, +6 authors N. Turgeon
- Journal of the American Society of Nephrology…
- 1 July 2016
The data strongly suggest that PSA screening for prostate cancer may be more harmful than protective in renal transplant candidates because it does not appear to confer a survival benefit to these candidates and may delay listing and decrease transplantation rates. Expand
Proposal for a new T-stage classification system for distal cholangiocarcinoma: a 10-institution study from the U.S. Extrahepatic Biliary Malignancy Consortium.
- L. M. Postlewait, Cecilia G Ethun, +20 authors S. Maithel
- HPB : the official journal of the International…
- 1 October 2016
This proposed T-stage classification, based on tumor size and LVI, better differentiates patient outcomes after resection and could be considered for incorporation into the next AJCC distal cholangiocarcinoma staging system. Expand
Targeting the interleukin-17 immune axis for cancer immunotherapy
Current knowledge in harnessing IL-17–producing γδ and Th17 cells for successful cancer immunotherapy is summarized. Expand