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Titanium Catalysis in the Ugi Reaction of α-Amino Acids with Aromatic Aldehydes
Ugi reaction between an (S)-α-amino acid, an aromatic aldehyde, and an isonitrile proceeds best under catalysis by TiCl4 in MeOH. The sense of diastereoinduction is (S,S).
Unified biomimetic assembly of voacalgine A and bipleiophylline via divergent oxidative couplings.
TLDR
A unified oxidative coupling protocol between indole derivatives and 2,3-dihydroxybenzoic acid, mediated by silver oxide, has been developed to produce the core of bipleiophylline and of its biosynthetic precursor, voacalgine A.
Direct oxidative coupling of N-acetyl indoles and phenols for the synthesis of benzofuroindolines related to phalarine.
TLDR
An oxidative coupling between phenol and N-acetyl indoles was designed, mediated by 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and FeCl3, which allowed the regioselective synthesis of benzofuro[3,2-b]indolines, whose structure is found in the natural product phalarine.
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