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Determination of atomic desolvation energies from the structures of crystallized proteins.
We estimated effective atomic contact energies (ACE), the desolvation free energies required to transfer atoms from water to a protein's interior, using an adaptation of a method introduced by S.…
ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes.
ALK-negative ALCL is a genetically heterogeneous disease with widely disparate outcomes following standard therapy, and DUSP22 and TP63 rearrangements may serve as predictive biomarkers to help guide patient management.
Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing.
These findings represent the first recurrent translocation reported in ALK-negative ALCL and highlight the utility of massively parallel genomic sequencing to discover novel translocations in lymphoma and other cancers.
USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis.
- Ying Zhang, O. Foreman, P. Galardy
- Biology, MedicineThe Journal of clinical investigation
- 3 December 2012
A mouse lacking Usp44 was engineered and it was found that USP44 regulated the mitotic checkpoint and prevented chromosome lagging, revealing a new role for the ubiquitin system in mitotic spindle regulation.
DNA-Mediated Fluctuations in Ionic Current through Silicon Oxide Nanopore Channels. Nano Lett., 4(8), 1551-1556
This work has fabricated nanopore “channel” sensors with a silicon oxide inner surface, and the results challenge the prevailing view of exclusive mechanica, which believes that there exists no electrical interaction between the nanopore and the translocating molecule.
Anaplastic lymphoma kinase immunoreactivity correlates with ALK gene rearrangement and transcriptional up-regulation in non-small cell lung carcinomas.
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation.
Novel markers for enterochromaffin cells and gastrointestinal neuroendocrine carcinomas
This study identified genes, which possess relatively specific expression to enterochromaffin and neuroendocrine carcinoma cells and genes with differential expression between primary tumors and metastases and verified six novel marker genes that may be developed as biomarkers and/or therapeutic targets.
The role of desmoglein-3 in the diagnosis of squamous cell carcinoma of the lung.
DSG3 was over-expressed in SQCCs but had very limited expression in both adenocarcinomas and non-neoplastic lungs, and can be a useful ancillary marker to separate SQCC from other subtypes of lung cancer.
Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.
Together, these findings identify VAV1 fusions as recurrent and targetable events in PTCLs and highlight the potential for clinical sequencing to guide individualized therapy approaches for this group of aggressive malignancies.