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Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation
Recent studies have shown that mesenchymal stem cell (MSC)‐based therapy might be an effective approach for the treatment of intervertebral disc degeneration (IDD). However, many unanswered questionsExpand
Coculture of Bone Marrow Mesenchymal Stem Cells and Nucleus Pulposus Cells Modulate Gene Expression Profile Without Cell Fusion
Study Design. Changes in gene expression profile and cell fusion of mesenchymal stem cells (MSC) and nucleus pulposus cells (NPC) after coculture were analyzed. Objective. To investigate theExpand
Feasibility of a stem cell therapy for intervertebral disc degeneration.
BACKGROUND CONTEXT Different strategies to supplement/replenish the disc cell population have been proposed. Recently, adult stem cells have shown promise as a cell source for a variety of tissueExpand
Characterization of Intervertebral Disc Aging: Longitudinal Analysis of a Rabbit Model by Magnetic Resonance Imaging, Histology, and Gene Expression
Study Design. A cohort of young, healthy New Zealand White rabbits was followed longitudinally with serial magnetic resonance imaging (MRI) analysis and terminal analysis of histologic changes andExpand
Use of an antifibrotic agent improves the effect of platelet-rich plasma on muscle healing after injury.
BACKGROUND Muscle contusions are a common type of muscle injury and are frequently encountered in athletes and military personnel. Although these injuries are capable of healing in most instances,Expand
Effect of bupivacaine on intervertebral disc cell viability.
BACKGROUND CONTEXT Bupivacaine is a local anesthetic commonly used to relieve or control pain in interventional spine procedures. Bupivacaine has been shown to be toxic to articular cartilage, whichExpand
The transpedicular approach for the study of intervertebral disc regeneration strategies: in vivo characterization
PurposeTo characterize in vivo the transpedicular approach (TA) as an alternative route to study intervertebral disc (IVD) regeneration strategies in a sheep model.Methods48 IVD of 12 sheep wereExpand
Poly-l-Lactic Acid/Hydroxyapatite Electrospun Nanocomposites Induce Chondrogenic Differentiation of Human MSC
Cartilage and bone tissue engineering has been widely investigated but is still hampered by cell differentiation and transplant integration issues within the constructs. Scaffolds represent theExpand
Intervertebral disc regeneration: from the degenerative cascade to molecular therapy and tissue engineering
Low back pain is one of the major health problems in industrialized countries, as a leading source of disability in the working population. Intervertebral disc degeneration has been identified as itsExpand
2D and 3D 3-tesla magnetic resonance imaging of the double bundle structure in anterior cruciate ligament anatomy
For anterior cruciate ligament (ACL) surgery using the anatomic approach of the double bundle concept it is helpful to describe the anteromedial (AM) and posterolateral (PL) bundle using MagneticExpand