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Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines.
A monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues is developed and used to investigate SSX expression in normal testis and thyroid, benign melanocytic lesions, melanoma lesions, and melanoma cell lines. Expand
Stromal Cell-Derived Factor-1α Promotes Melanoma Cell Invasion across Basement Membranes Involving Stimulation of Membrane-Type 1 Matrix Metalloproteinase and Rho GTPase Activities
The identification of SDF-1α as a potential stimulatory molecule for MT1-MMP as well as for RhoA and Rac1 activities during melanoma cell invasion, associated with an up-regulation in CXCR4 expression by interaction with basement membrane factors, could contribute to better knowledge of mechanisms stimulating melanomacell dissemination. Expand
Matrix metalloproteinases in human melanoma.
It is concluded that the balance between levels of activated matrix metalloproteinases and expression levels of their tissue inhibitors, and the coexpression of activates and adhesion molecules are important factors in determining melanoma cell invasion, tumor growth, and metastasis formation. Expand
Expression of Functional Chemokine Receptors CXCR3 and CXCR4 on Human Melanoma Cells*
Chemokines are secreted into the tumor microenvironment by tumor-infiltrating inflammatory cells as well as by tumor cells. Chemokine receptors mediate agonist-dependent cell responses, includingExpand
nmb, a novel gene, is expressed in low‐metastatic human melanoma cell lines and xenografts
From a subtractive cDNA library, we isolated several cDNA clones which showed differential expression between highly and lowly metastatic human melanoma cell lines. One clone, designated nmb, showedExpand
Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity.
Comparative studies of two-dimensional monolayer and three-dimensional collagen-gel cultures revealed that extensive cell-to-cell contacts, wild-type ALCAM, and cell- to-matrix interactions were all indispensable for efficient conversion of pro-MMP-2 to its active form in metastatic melanoma cells, supporting its previously postulated sensor function in invasive growth. Expand
Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state.
It is demonstrated that in vitro-generated mature, but not immature dendritic cells, efficiently migrate into the T-cell areas of lymph nodes of melanoma patients. Expand
Establishment and characterization of a human melanoma cell line (MV3) which is highly metastatic in nude mice
Only few human melanoma cell lines are available that frequently show metastasis in nude mice, the highly metastatic MV3 cell line represents a useful tool for studying the expression and regulation of molecules onhuman melanoma cells involved in the process of metastasis. Expand
Expression and activation of matrix metalloproteinase‐2 (MMP‐2) and its co‐localization with membrane‐type 1 matrix metalloproteinase (MT1‐MMP) correlate with melanoma progression
This study demonstrates that expression of MT1‐MMP and TIMP‐2 and activation of MMP‐2 are correlated with tumour progression both in the xenograft model and in human melanocytic lesions, strongly suggesting that these factors are required for melanoma invasion and metastasis formation. Expand
E‐cadherin expression in human melanoma
Flowcytometrical analysis demonstrated that E-cadherin was expressed on cultured normal melanocytes and naevus cells, and it is rarely found in early stages of melanocytic tumour progression in situ and, surprisingly, some expression can be observed in 10–20% of lesions of advanced stages. Expand