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A permanent change in brain function resulting from daily electrical stimulation.
High-intensity stimulation studies revealed that the development of convulsions was not based simply on threshold reduction, but involved complex reorganization of function.
Development of Epileptic Seizures through Brain Stimulation at Low Intensity
- G. V. Goddard
- 1 June 1967
This note does not debate this temporary elevation of convulsion threshold but rather emphasizes an equally important phenomenon in which, over a longer period of time, the convulsive threshold is reduced.
Synaptic enhancement in fascia dentata: Cooperativity among coactive afferents
Evidence is presented that long-lasting enhancement of perforant path synapses following high-frequency activity is a cooperative process requiring coactivity of a considerable number of fibers. This…
Maintenance of long-term potentiation in rat dentate gyrus requires protein synthesis but not messenger RNA synthesis immediately post-tetanization
- S. Otani, C. Marshall, W. Tate, G. V. Goddard, W. Abraham
- Medicine, BiologyNeuroscience
- 31 December 1989
It is suggested that for long-term potentiation of the excitatory postsynaptic potential to be maintained for at least 3 h proteins must be synthesized from already existing messenger ribonucleic acid, and that this synthesis is mostly completed within 15 min after tetanization.
Heterosynaptic changes accompany long‐term but not short‐term potentiation of the perforant path in the anaesthetized rat.
Although effects of long‐term E‐S potentiation in rats anaesthetized with sodium pentobarbitone probably reflect a generalized post‐synaptic change, this change is unlikely to be a prolonged reduction in the membrane potential of granule cells.
Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus
The results imply that the efficiency of synaptic transmission in the perforant path-granule cell synapse can be modified.
Reduction of long‐term potentiation in the dentate gyrus of the rat following selective depletion of monoamines.
Results show that monoamines can modulate long‐term changes in synaptic function in the dentate gyrus, and suggest that 5‐HT is more potent in this respect than NA, and the effect of monoamine depletion on granule cell excitability was investigated.
Commissural inhibition and facilitation of granule cell discharge in fascia dentata
- R. Douglas, B. McNaughton, G. V. Goddard
- Biology, MedicineThe Journal of comparative neurology
- 20 September 1983
The results imply that the initial main effect on fascia dentata granule cells of activity in the contralateral hilus is a γ‐aminobutyric‐acid‐mediated inhibition, which most probably involves commissural excitation of local inhibitory interneurons.
Asymmetric relationships between homosynaptic long-term potentiation and heterosynaptic long-term depression
It is reported that tetanization of either MPP or LPP reliably depresses synaptic transmission in the other pathway for at least 3 h, considerably smaller than the usual magnitude of LTP, and was obtained regardless of whether LTP had been produced in the tetanized homosynaptic pathway.
Field potential evidence for long-term potentiation of feed-forward inhibition in the rat dentate gyrus
- E. W. Kairiss, W. Abraham, D. Bilkey, G. V. Goddard
- Medicine, ChemistryBrain Research
- 13 January 1987
Perforant path/granule cell LTP is normally accompanied by long-term potentiation of a feed-forward inhibitory pathway which may involve interneurones, and picrotoxin blocked the decrease in slope of the E-S relationship which normally accompanies LTP.