• Publications
  • Influence
Activity-dependent scaling of quantal amplitude in neocortical neurons
TLDR
A new form of synaptic plasticity is described that increases or decreases the strength of all of a neuron's synaptic inputs as a function of activity, and may help to ensure that firing rates do not become saturated during developmental changes in the number and strength of synaptic inputs. Expand
Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity
TLDR
A novel form of cooperativity operating even when postsynaptic firing is evoked by current injection is demonstrated, and a complex dependence of LTP and LTD on rate and timing is revealed, providing a quantitative framework for predicting the impact of in vivo firing patterns on synaptic strength. Expand
Homeostatic plasticity in the developing nervous system
TLDR
Evidence is discussed from a number of systems that homeostatic synaptic plasticity is crucial for processes ranging from memory storage to activity-dependent development, and how these processes maintain stable activity states in the face of destabilizing forces is discussed. Expand
The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses
TLDR
Current evidence suggests that neurons detect changes in their own firing rates through a set of calcium-dependent sensors that then regulate receptor trafficking to increase or decrease the accumulation of glutamate receptors at synaptic sites. Expand
Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid Receptors
TLDR
TLTD requires simultaneous activation of presynaptic NMDA and CB1 receptors and this novel form of coincidence detection may explain the temporal window of tLTD and may also impart synapse specificity to cannabinoid retrograde signaling. Expand
Plasticity in the intrinsic excitability of cortical pyramidal neurons
TLDR
It is demonstrated that in response to changes in activity, cultured cortical pyramidal neurons regulate intrinsic excitability to promote stability in firing by selectively regulating voltage-dependent conductances. Expand
Stable Hebbian Learning from Spike Timing-Dependent Plasticity
TLDR
The results indicate that stable correlation-based plasticity can be achieved without introducing competition, suggesting that plasticity and competition need not coexist in all circuits or at all developmental stages. Expand
Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing
TLDR
Cortical neurons thus homeostatically adjust synaptic strengths in response to changes in their own firing rate, a mechanism with the computational advantage of efficiently normalizing synaptic strengths without interfering with synapse-specific mechanisms of information storage. Expand
Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement.
  • G. Turrigiano
  • Biology, Medicine
  • Annual review of neuroscience
  • 21 June 2011
TLDR
Where and when homeostatic mechanisms that regulate neuronal and circuit excitability are used in complex microcircuits are discussed, what is currently known about the signaling pathways that underlie them, and how these different ways of achieving network stability cooperate and/or compete are discussed. Expand
Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same
TLDR
Recently, several forms of homeostatic plasticity that stabilize the properties of neural circuits have been identified, and these include mechanisms that regulate neuronal excitability, stabilize total synaptic strength, and influence the rate and extent of synapse formation. Expand
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