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Activity-dependent scaling of quantal amplitude in neocortical neurons
Information is stored in neural circuits through long-lasting changes in synaptic strengths,. Most studies of information storage have focused on mechanisms such as long-term potentiation andExpand
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Rate, Timing, and Cooperativity Jointly Determine Cortical Synaptic Plasticity
Cortical long-term plasticity depends on firing rate, spike timing, and cooperativity among inputs, but how these factors interact during realistic patterns of activity is unknown. Here we monitoredExpand
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Homeostatic plasticity in the developing nervous system
Activity has an important role in refining synaptic connectivity during development, in part through 'Hebbian' mechanisms such as long-term potentiation and long-term depression. However, HebbianExpand
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Neocortical LTD via Coincident Activation of Presynaptic NMDA and Cannabinoid Receptors
There is a consensus that NMDA receptors (NMDARs) detect coincident pre- and postsynaptic activity during induction of long-term potentiation (LTP), but their role in timing-dependent long-termExpand
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The Self-Tuning Neuron: Synaptic Scaling of Excitatory Synapses
Homeostatic synaptic scaling is a form of synaptic plasticity that adjusts the strength of all of a neuron's excitatory synapses up or down to stabilize firing. Current evidence suggests that neuronsExpand
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Plasticity in the intrinsic excitability of cortical pyramidal neurons
During learning and development, the level of synaptic input received by cortical neurons may change dramatically. Given a limited range of possible firing rates, how do neurons maintainExpand
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Stable Hebbian Learning from Spike Timing-Dependent Plasticity
We explore a synaptic plasticity model that incorporates recent findings that potentiation and depression can be induced by precisely timed pairs of synaptic events and postsynaptic spikes. InExpand
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Rapid Synaptic Scaling Induced by Changes in Postsynaptic Firing
Homeostatic synaptic scaling adjusts a neuron's excitatory synaptic strengths up or down to compensate for perturbations in activity. Little is known about the molecular pathway(s) involved, nor isExpand
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Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement.
  • G. Turrigiano
  • Medicine, Biology
  • Annual review of neuroscience
  • 21 June 2011
Maintaining the proper balance between excitation and inhibition is critical for the normal function of cortical circuits. This balance is thought to be maintained by an array of homeostaticExpand
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Critical periods for experience-dependent synaptic scaling in visual cortex
The mechanisms underlying experience-dependent plasticity and refinement of central circuits are not yet fully understood. A non-Hebbian form of synaptic plasticity, which scales synaptic strengthsExpand
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