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Fungal secondary metabolism — from biochemistry to genomics
TLDR
Questions are addressed, including which evolutionary pressures led to gene clustering, why closely related species produce different profiles of secondary metabolites, and whether fungal genomics will accelerate the discovery of new pharmacologically active natural products.
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SMURF: Genomic mapping of fungal secondary metabolite clusters.
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Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
TLDR
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors.
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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
TLDR
The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
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Insertional polymorphisms of full-length endogenous retroviruses in humans
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Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus
We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri…
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Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans
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Transfer of Genes Coding for Apoproteins of Reaction Centre and Light-harvesting LH1 Complexes to Rhodobacter sphaeroides
TLDR
The efficiency of transfer was sufficiently high to enable a bank of R b.
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Transformation of Aspergillus nidulans by the orotidine-5'-phosphate decarboxylase gene of Neurospora crassa.
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Nuclear and extranuclear inheritance of oligomycin resistance in Aspergillus nidulans
TLDR
While the nuclear mutants showed no abnormalities on drug-free medium, the extranuclear mutant exhibited impaired growth ability, and this character never segregated from the oligomycin-resistance character in any of the genetic experiments carried out.
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