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Transcranial ultrasound in clinical sonothrombolysis (TUCSON) trial
TLDR
A randomized multicenter phase II trial of μS dose escalation with systemic thrombolysis is reported, finding μS reaches intracranial occlusions and transmit energy momentum from an ultrasound wave to residual flow to promote recanalization.
Safety and Efficacy of Ultrasound-Enhanced Thrombolysis: A Comprehensive Review and Meta-Analysis of Randomized and Nonrandomized Studies
TLDR
A meta-analysis evaluated the safety and efficacy of ultrasound-enhanced thrombolysis compared to the current standard of care (intravenous tPA) and found the present safety and signal-of-efficacy data should be taken into account in the design of future randomized controlled trials.
European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke
TLDR
These European Stroke Organisation guidelines provide evidence-based recommendations to assist physicians in their clinical decisions with regard to intravenous thrombolysis for acute ischaemic stroke and provide further recommendations regarding patient subgroups, late time windows, imaging selection strategies, relative and absolute contraindications to alteplase, and tenecteplase.
Asian-Pacific perspective on the psychological well-being of healthcare workers during the evolution of the COVID-19 pandemic
TLDR
The multivariable analysis found that non-medically trained personnel, the presence of physical symptoms and presence of prior medical conditions were independent predictors across the participating countries.
Multicenter external validation of the ABCD2 score in triaging TIA patients
TLDR
The findings externally validate the usefulness of the ABCD2 score in triaging TIA patients with a high risk of early stroke in a multiethnic sample of hospitalized patients and support current guidelines endorsing the immediate hospitalization of patients with an ABCD 2 score >2.
Practice Standards for Transcranial Doppler (TCD) Ultrasound. Part II. Clinical Indications and Expected Outcomes
TLDR
Transcranial Doppler is a physiological ultrasound test with established safety and efficacy and the end‐result provided by imaging duplex or nonimaging TCD is sampling physiological flow variables through the spectral waveform assessment.
Advances in transcranial doppler ultrasonography
Transcranial Doppler ultrasonography (TCD) is the only noninvasive real-time neuroimaging modality for the evaluation of characteristics of blood flow in basal intracerebral vessels that adds
Validation of Transcranial Doppler With Computed Tomography Angiography in Acute Cerebral Ischemia
TLDR
Bedside TCD examination yields satisfactory agreement with urgent brain CTA in the evaluation of patients with acute cerebral ischemia, and TCD can provide real-time flow findings that are complementary to information provided by CTA.
Velocity Criteria for Intracranial Stenosis Revisited: An International Multicenter Study of Transcranial Doppler and Digital Subtraction Angiography
TLDR
Novel velocity/ratio criteria for ≥70% stenosis increased sensitivity and showed good agreement with invasive angiography and SONIA mean flow velocity criteria remain reliably predictive of ≥50% stenoses at laboratories with a standardized scanning protocol.
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