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Clinical and economic burden of adverse drug reactions
Adverse drug reactions (ADRs) are unwanted drug effects that have considerable economic as well as clinical costs as they often lead to hospital admission, prolongation of hospital stay and emergencyExpand
Epidemiology of gout and hyperuricaemia in Italy during the years 2005–2009: a nationwide population-based study
Objective To assess the epidemiology of gout and hyperuricaemia in the Italian general population during the years 2005–2009. Methods Using the Italian primary care database (Health Search/CSDExpand
Data mining on electronic health record databases for signal detection in pharmacovigilance: which events to monitor?
Data mining on electronic health records (EHRs) has emerged as a promising complementary method for post‐marketing drug safety surveillance. The EU‐ADR project, funded by the European Commission, isExpand
Patterns of persistence with antihypertensive medications in newly diagnosed hypertensive patients in Italy: a retrospective cohort study in primary care
Objective To describe patterns of persistence and related primary care costs associated with first antihypertensive treatment. Design and setting Retrospective cohort study during 2000–2001, usingExpand
Clinically Significant Drug Interactions with Newer Antidepressants
After the introduction of selective serotonin reuptake inhibitors (SSRIs), other newer antidepressants with different mechanisms of action have been introduced in clinical practice. BecauseExpand
Risk of stroke with typical and atypical anti-psychotics: a retrospective cohort study including unexposed subjects
The purpose of the study was to investigate the risk of stroke with typical and atypical anti-psychotics in elderly subjects, weighting for a number of known risk factors, including dementia. DataExpand
Systemic antibiotic prescribing to paediatric outpatients in 5 European countries: a population-based cohort study
BackgroundTo describe the utilisation of antibiotics in children and adolescents across 5 European countries based on the same drug utilisation measures and age groups. Special attention was given toExpand
All‐cause mortality associated with atypical and typical antipsychotics in demented outpatients
To estimate the association between use of typical and atypical antipsychotics and all‐cause mortality in a population of demented outpatients.
Antipsychotic prescribing pattern among Italian general practitioners: a population-based study during the years 1999–2002
ObjectivesTo assess the antipsychotic use and the prevalence/incidence of antipsychotic drug users in Italy during the years 1999–2002. To estimate the persistence with antipsychotic medications, andExpand
A Reference Standard for Evaluation of Methods for Drug Safety Signal Detection Using Electronic Healthcare Record Databases
BackgroundThe growing interest in using electronic healthcare record (EHR) databases for drug safety surveillance has spurred development of new methodologies for signal detection. Although severalExpand