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Human Relaxin Gene 3 (H3) and the Equivalent Mouse Relaxin (M3) Gene
We have identified a novel human relaxin gene, designated H3 relaxin, and an equivalent relaxin gene in the mouse from the Celera Genomics data base. Both genes encode a putative prohormone sequenceExpand
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Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.
The amino-terminal amino acid sequence and several internal peptide sequences of angiotensin I-converting enzyme (ACE; peptidyl-dipeptidase A, kininase II; EC 3.4.15.1) purified from human kidneyExpand
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Cloning of cDNA for a stylar glycoprotein associated with expression of self-incompatibility in Nicotiana alata
Self-incompatibility in flowering plants is controlled by the S gene. A complementary DNA clone encoding a style protein of Nicotiana alata which segregates with the S2 allele has now been sequenced.Expand
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Evolution of the relaxin-like peptide family
BackgroundThe relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL)Expand
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Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo.
Cardiac fibrosis is a key component of heart disease and involves the proliferation and differentiation of matrix-producing fibroblasts. The effects of an antifibrotic peptide hormone, relaxin, inExpand
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Mice without a functional relaxin gene are unable to deliver milk to their pups.
We have used gene targeting to generate relaxin (rlx)-deficient mice. The majority (15 of 17) of homozygous (rlx-/-) mice are fertile and produce normal litters. However their mammary development isExpand
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Relaxin gene expression in human ovaries and the predicted structure of a human preprorelaxin by analysis of cDNA clones.
In earlier studies we identified in a human genomic library a gene (human relaxin gene H1) coding for a relaxin‐related peptide. We now have evidence that the human genome possesses an additionalExpand
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Location of the major antigenic sites involved in rotavirus serotype-specific neutralization.
Antigenic sites on the rotavirus major outershell glycoprotein were identified by using mutant viruses selected for resistance to neutralizing (serotype-specific) monoclonal antibodies. TheExpand
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Restricted, but abundant, expression of the novel rat gene‐3 (R3) relaxin in the dorsal tegmental region of brain
Relaxin is a peptide hormone with known actions associated with female reproductive physiology, but it has also been identified in the brain. Only one relaxin gene had been characterized in rodentsExpand
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Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2
The hormone relaxin inhibits renal myofibroblast differentiation by interfering with TGF‐β1/ Smad2 signaling. However, the pathways involved in the relaxin‐TGF‐β1/Smad2 interaction remain unknown.Expand
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