G. Torri | Semantic Scholar

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

M. Guerrini, D. Beccati, R. Sasisekharan
Biology
Nature Biotechnology
1 June 2008

Through detailed structural analysis, the contaminant was found to contain a disaccharide repeat unit of glucuronic acid linked β1→3 to a β-N-acetylgalactosamine, indicative of an allergic-type reaction.

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Modulation of the Heparanase-inhibiting Activity of Heparin through Selective Desulfation, Graded N-Acetylation, and Glycol Splitting*

A. Naggi, B. Casu, I. Vlodavsky
Biology, Chemistry
Journal of Biological Chemistry
1 April 2005

The combination of high inhibition of heparanase and low release/potentiation of ECM-bound growth factor indicates that N-acetylated, glycol-split heparins are potential antiangiogenic and antimetastatic agents that are more effective than their counterparts with unmodified backbones.

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SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

J. Ritchie, Vishnu C. Ramani, Yang Yang
Biology, Medicine
Clinical Cancer Research
21 January 2011

These results provide mechanistic insight into the antitumor action of SST0001 and validate its use as a novel therapeutic tool for treating multiple myeloma.

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Conformer populations of L-iduronic acid residues in glycosaminoglycan sequences.

D. Ferro, A. Provasoli, J. Choay
Chemistry, Biology
Carbohydrate research
15 January 1990

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Structural differences between non-wood plant celluloses: evidence from solid state NMR, vibrational spectroscopy and X-ray diffractometry

B. Focher, M. Palma, M. Canetti, G. Torri, C. Cosentino, G. Gastaldi
Materials Science
1 May 2001

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Combined quantitative (1)H and (13)C nuclear magnetic resonance spectroscopy for characterization of heparin preparations.

M. Guerrini, A. Bisio, G. Torri
Chemistry
Seminars in thrombosis and hemostasis
1 October 2001

The sulfation patterns of pig and bovine mucosal commercial heparin preparations can be characterized and distinguished from each other easily by analysis of their monodimensional proton and carbon…

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Structural features of low-molecular-weight heparins affecting their affinity to antithrombin.

A. Bisio, D. Vecchietti, G. Torri
Biology
Thrombosis and haemostasis
21 September 2009

Enoxaparin is consistently richer in shorter oligosaccharides than Tinzaparin and Dalteparin, and this study is critical for establishing correlations between structural features of LMWHs and their AT-mediated anticoagulant activity.

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Alkaline N-deacetylation of chitin enhanced by flash treatments. Reaction kinetics and structure modifications

B. Focher, P. Beltrame, A. Naggi, G. Torri
Chemistry
1990

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1H and 13C NMR spectral assignments of the major sequences of twelve systematically modified heparin derivatives.

E. Yates, F. Santini, M. Guerrini, A. Naggi, G. Torri, B. Casu
Chemistry
Carbohydrate research
20 November 1996

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Conformation of heparin pentasaccharide bound to antithrombin III.

M. Hricovíni, M. Guerrini, A. Bisio, G. Torri, M. Petitou, B. Casu
Chemistry, Biology
The Biochemical journal
15 October 2001

An analysis of the three-dimensional structures of the pentasaccharide in the free state, and in the complex, revealed the binding to be accompanied by dihedral angle variation at the A-G and I-A(M) glycosidic linkages.

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