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Control of human vascular tone by prostanoids derived from perivascular adipose tissue.
Perivascular adipose tissue (PVAT) surrounds most vessels and has now been recognized as a regulator of vascular functions. This effect of PVAT has been mostly demonstrated in vessels obtained fromExpand
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Human perivascular adipose tissue dysfunction as a cause of vascular disease: Focus on vascular tone and wall remodeling.
Obesity is one of the major risk factors for the development of cardiovascular diseases. It is characterized by excessive or abnormal accumulation of adipose tissue, including depots which surroundExpand
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Endothelial Thrombomodulin Induces Ca2+ Signals and Nitric Oxide Synthesis through Epidermal Growth Factor Receptor Kinase and Calmodulin Kinase II*
Endothelial membrane-bound thrombomodulin is a high affinity receptor for thrombin to inhibit coagulation. We previously demonstrated that the thrombin-thrombomodulin complex restrains cellExpand
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Prostaglandin E₂ induced contraction of human intercostal arteries is mediated by the EP₃ receptor.
Arterial vascularization of the spinal cord may be mechanically or functionally altered during thoraco-abdominal surgery/intravascular procedures. Increased arterial pressure has been shown toExpand
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The role of perivascular adipose tissue on human saphenous vein vascular tone
Perivascular adipose tissue (PVAT) is situated outside of almost every blood vessel. Recent studies showed that PVAT provides mechanical support for blood vessels and secretes vasoactive adipokinesExpand
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Inhibition of microsomal PGE synthase‐1 reduces human vascular tone by increasing PGI2: a safer alternative to COX‐2 inhibition
The side effects of cyclooxygenase‐2 (COX‐2) inhibitors on the cardiovascular system could be associated with reduced prostaglandin (PG)I2 synthesis. Microsomal PGE synthase‐1 (mPGES‐1) catalyses theExpand
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Reverse Regulatory Pathway (H2S / PGE2 / MMP) in Human Aortic Aneurysm and Saphenous Vein Varicosity
Hydrogen sulfide (H2S) is a mediator with demonstrated protective effects for the cardiovascular system. On the other hand, prostaglandin (PG)E2 is involved in vascular wall remodeling by regulatingExpand
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Resveratrol improves high-fructose-induced vascular dysfunction in rats.
High levels of fructose in the diet results in metabolic abnormalities and vascular disorders. In this study, the effect of resveratrol (RES) on vascular relaxation and contraction responses wasExpand
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mPGES-1 inhibitor reduces human vascular tone by increasing PGI2: a safer alternative to COXIBs
Background and Purpose The side effects of cyclooxygenase-2 (COX-2) inhibitors (COXIBs) on the cardiovascular system could be associated with a reduced prostaglandin (PG) I2 synthesis. MicrosomalExpand
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Involvement of prostaglandin F2α in preeclamptic human umbilical vein vasospasm: a role of prostaglandin F and thromboxane A2 receptors
Objective Preeclampsia is characterized by hypertension and proteinuria developing after 20 weeks of gestation. Increased vasoconstriction can be one of the major underlying pathophysiological eventExpand
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