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- Publications
- Influence
Cardiac growth in rainbow trout, Salmo gairdneri
- A. P. Farrell, A. M. Hammons, M. S. Graham, G. Tibbits
- Biology
- 1 November 1988
Relative ventricular mass, percent compact myocardium, total protein, DNA content, and myocyte size were determined for rainbow trout, Salmo gairdneri, ranging in size from 10 to 2000 g. Ventricular… Expand
Cardiac physiology in tunas. II. Effect of ryanodine, calcium, and adrenaline on force–frequency relationships in atrial strips from skipjack tuna, Katsuwonus pelamis
- J. E. Keen, A. Farrell, G. Tibbits, R. Brill
- Biology
- 1 June 1992
Force–frequency relationships and the dependence upon extracellular calcium as a source of activator calcium were investigated using atrial strips from the skipjack tuna (Katsuwonus pelamis). At 25… Expand
Effect of temperature and temperature acclimation on the ryanodine sensitivity of the trout myocardium
- J. E. Keen, D. -. Vianzon, A. Farrell, G. Tibbits
- Biology
- Journal of Comparative Physiology B
- 2004
The influence of acute temperature change and temperature acclimation on the sensitivity of contracture development to ryanodine were examined in the rainbow trout myocardium using two preparations:… Expand
THERMAL ACCLIMATION ALTERS BOTH ADRENERGIC SENSITIVITY AND ADRENOCEPTOR DENSITY IN CARDIAC TISSUE OF RAINBOW TROUT
- J. E. Keen, D. Vianzon, A. Farrell, G. Tibbits
- Biology
- 1 August 1993
We examined the effect of temperature acclimation on the sensitivity of the rainbow trout heart to adrenaline and on the density of beta-adrenoceptors. The sensitivity of the heart was assessed using… Expand
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Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.
- P. Dan, Eric Lin, Jingbo Huang, P. Biln, G. Tibbits
- Biology, Medicine
- Biophysical journal
- 1 October 2007
Mechanisms of cardiac excitation-contraction coupling in neonates are still not clearly defined. Previous work in neonates shows reverse-mode Na(+)-Ca(2+) exchange to be the primary route of Ca(2+)… Expand
Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.
- F. Sedarat, L. Xu, E. Moore, G. Tibbits
- Biology, Medicine
- American journal of physiology. Heart and…
- 1 July 2000
Because of undeveloped T tubules and sparse sarcoplasmic reticulum, Ca(2+)-induced Ca(2+) release (CICR) may not be the major mechanism providing contractile Ca(2+) in the neonatal heart. Spatial… Expand
Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.
- B. Liang, Franca Chung, +5 authors G. Tibbits
- Biology, Medicine
- Physiological genomics
- 1 April 2008
The cardiac troponin C (cTnC) mutation, L29Q, has been found in a patient with familial hypertrophic cardiomyopathy. We previously showed that L29, together with neighboring residues, Asp2, Val28,… Expand
Calcium transport and the regulation of cardiac contractility in teleosts: a comparison with higher vertebrates
- G. Tibbits, L. Hove-Madsen, D. Bers
- Biology
- 1 July 1991
Active teleosts such as the salmonids must vary cardiac output severalfold over a wide range of temperatures. Myocardial contractility, an important determinant of cardiac output, must be maintained… Expand
Temperature and pH effects on Ca2+ sensitivity of cardiac myofibrils: a comparison of trout with mammals.
- C. S. Churcott, C. Moyes, B. Bressler, K. Baldwin, G. Tibbits
- Biology, Medicine
- The American journal of physiology
- 1 July 1994
Active salmonids maintain myocardial contractility at temperatures that are cardioplegic for mammals. We postulated that myofibrillar Ca2+ sensitivity in the trout heart might 1) exhibit lower… Expand
Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*
- A. Li, C. M. Stevens, +4 authors G. Tibbits
- Chemistry, Medicine
- PloS one
- 18 November 2013
The Ca2+ binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned… Expand