G. Tibbits

Publications162
h-index34
Citations3,000
Highly Influential Citations182
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Cardiac growth in rainbow trout, Salmo gairdneri
Relative ventricular mass, percent compact myocardium, total protein, DNA content, and myocyte size were determined for rainbow trout, Salmo gairdneri, ranging in size from 10 to 2000 g. Ventricular… Expand
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Cardiac physiology in tunas. II. Effect of ryanodine, calcium, and adrenaline on force–frequency relationships in atrial strips from skipjack tuna, Katsuwonus pelamis
Force–frequency relationships and the dependence upon extracellular calcium as a source of activator calcium were investigated using atrial strips from the skipjack tuna (Katsuwonus pelamis). At 25… Expand
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Effect of temperature and temperature acclimation on the ryanodine sensitivity of the trout myocardium
The influence of acute temperature change and temperature acclimation on the sensitivity of contracture development to ryanodine were examined in the rainbow trout myocardium using two preparations:… Expand
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THERMAL ACCLIMATION ALTERS BOTH ADRENERGIC SENSITIVITY AND ADRENOCEPTOR DENSITY IN CARDIAC TISSUE OF RAINBOW TROUT
We examined the effect of temperature acclimation on the sensitivity of the rainbow trout heart to adrenaline and on the density of beta-adrenoceptors. The sensitivity of the heart was assessed using… Expand
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Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.
Mechanisms of cardiac excitation-contraction coupling in neonates are still not clearly defined. Previous work in neonates shows reverse-mode Na(+)-Ca(2+) exchange to be the primary route of Ca(2+)… Expand
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Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.
Because of undeveloped T tubules and sparse sarcoplasmic reticulum, Ca(2+)-induced Ca(2+) release (CICR) may not be the major mechanism providing contractile Ca(2+) in the neonatal heart. Spatial… Expand
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Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.
The cardiac troponin C (cTnC) mutation, L29Q, has been found in a patient with familial hypertrophic cardiomyopathy. We previously showed that L29, together with neighboring residues, Asp2, Val28,… Expand
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Calcium transport and the regulation of cardiac contractility in teleosts: a comparison with higher vertebrates
Active teleosts such as the salmonids must vary cardiac output severalfold over a wide range of temperatures. Myocardial contractility, an important determinant of cardiac output, must be maintained… Expand
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Temperature and pH effects on Ca2+ sensitivity of cardiac myofibrils: a comparison of trout with mammals.
Active salmonids maintain myocardial contractility at temperatures that are cardioplegic for mammals. We postulated that myofibrillar Ca2+ sensitivity in the trout heart might 1) exhibit lower… Expand
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Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*
The Ca2+ binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned… Expand
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