G. Tibbits

Publications176
h-index36
Citations3,231
Highly Influential Citations168
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Cardiac growth in rainbow trout, Salmo gairdneri
TLDR
It is suggested that long-term cardiac growth in rainbow trout involves both hyperplasia and hypertrophy.
Cardiac physiology in tunas. II. Effect of ryanodine, calcium, and adrenaline on force–frequency relationships in atrial strips from skipjack tuna, Katsuwonus pelamis
TLDR
Force–frequency relationships and the dependence upon extracellular calcium as a source of activator calcium were investigated using atrial strips from the skipjack tuna and Ryanodine, a blocker of calcium release from the sarcoplasmic reticulum, decreased active force but did not alter the shape of the force–frequency curve.
THERMAL ACCLIMATION ALTERS BOTH ADRENERGIC SENSITIVITY AND ADRENOCEPTOR DENSITY IN CARDIAC TISSUE OF RAINBOW TROUT
TLDR
Results suggest that cardiac tissue from rainbow trout acclimated to 8°C has a greater cell surface adrenoceptor population available for beta-antagonist binding, which might explain the heightened cardiac sensitivity to adrenaline observed in situ and in vitro in 6°C-acclimated fish.
Effect of temperature and temperature acclimation on the ryanodine sensitivity of the trout myocardium
TLDR
The results suggest that the sarcoplamic reticulum calcium release channel of the trout myocardium is expressed but is not functionally involved in beat-to-beat regulation of contractility at either a low temperature (8 °C), or at routine physiological heart rate (>0.6 Hz).
Three-dimensional distribution of cardiac Na+-Ca2+ exchanger and ryanodine receptor during development.
TLDR
In newborns, Ca (2+) influx via NCX could potentially activate the dense network of peripheral Ca(2+) stores via peripheral couplings, evoking Ca(1+)-induced Ca( 2+) release.
Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility.
TLDR
It is demonstrated that the L29Q mutation enhances the Ca(2+)-binding characteristics of cTnC and that when incorporated into cardiac myocytes, this mutant alters myocyte contractility.
Colocalization of dihydropyridine and ryanodine receptors in neonate rabbit heart using confocal microscopy.
TLDR
The results provide a structural basis for the diminished prominence of CICR in neonatal heart and find a significant increase in the degree of colocalization of DHPR and RyR during development.
Calcium transport and the regulation of cardiac contractility in teleosts: a comparison with higher vertebrates
TLDR
Teleosts and other lower vertebrates, release of Ca2+ from the sarcoplasmic reticulum appears to be less important than in mammals, based primarily on the following findings.
Temperature and pH effects on Ca2+ sensitivity of cardiac myofibrils: a comparison of trout with mammals.
TLDR
One mechanism by which the trout heart is able to maintain contractility at low temperatures is through the inherent higher Ca2+ sensitivity of the contractile element compared with mammalian species.
Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*
TLDR
This study demonstrates that the L29Q mutation alters the contractility and the functional effects of the phosphomimetic cTnI in both thin filament and single skinned cardiomyocytes and importantly that this effect is highly sarcomere length dependent.
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