• Publications
  • Influence
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations betweenExpand
  • 1,903
  • 169
  • PDF
Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary arteryExpand
  • 2,994
  • 163
  • PDF
Genetic studies of body mass index yield new insights for obesity biology
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body massExpand
  • 2,370
  • 155
  • PDF
Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes
We have previously reported suggestive linkage of type 2 diabetes mellitus to chromosome 10q. We genotyped 228 microsatellite markers in Icelandic individuals with type 2 diabetes and controlsExpand
  • 1,973
  • 141
Rate of de novo mutations and the importance of father’s age to disease risk
Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct a study of genome-wideExpand
  • 1,432
  • 120
  • PDF
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly but reproducibly influence risk of type 2 diabetes (T2D). Established associations to common andExpand
  • 1,765
  • 92
  • PDF
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic traits, we performed meta-analyses of 21 genome-wide association studies informative for fastingExpand
  • 1,810
  • 90
  • PDF
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Obesity results from the interaction of genetic and environmental factors. To search for sequence variants that affect variation in two common measures of obesity, weight and body mass index (BMI),Expand
  • 1,200
  • 85
  • PDF
Discovery and Refinement of Loci Associated with Lipid Levels
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary arteryExpand
  • 1,751
  • 82
  • PDF
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
To extend understanding of the genetic architecture and molecular basis of type 2 diabetes (T2D), we conducted a meta-analysis of genetic variants on the Metabochip, including 34,840 cases andExpand
  • 1,553
  • 78
  • PDF