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Activation of the hypothalamo-pituitary-adrenal axis by the growth hormone (GH) secretagogue, GH-releasing peptide-6, in rats.
GH-releasing hexapeptide (GHRP-6) is a synthetic secretagogue that stimulates the release of GH by acting at both hypothalamic and pituitary sites. GHRPs also consistently elicit small, but… Expand
Steroid feedback inhibition of pulsatile secretion of gonadotropin-releasing hormone in the ewe.
The long-term negative feedback effects of sustained elevations in circulating estradiol and progesterone on the pulsatile secretion of gonadotropin-releasing hormone (GnRH) and luteinizing hormone… Expand
Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep. Spontaneous secretion and response to insulin-induced hypoglycemia.
- L. Frohman, T. Downs, I. Clarke, G. Thomas
- Biology, Medicine
- The Journal of clinical investigation
- 1 July 1990
To elucidate the role of growth hormone (GH)-releasing hormone (GRH) and somatostatin (SRIH) in the regulation of the growth hormone (GH) secretory pattern, we collected portal blood from five… Expand
Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone (GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized…
- G. Thomas, J. Cummins, H. Francis, A. Sudbury, P. McCloud, I. Clarke
- Biology, Medicine
- 1 February 1991
These studies characterized the secretion of GH-releasing factor (GRF) and somatostatin (SRIF) into the hypophysial portal circulation in ewes after long term restricted feeding. In addition, we… Expand
GnRH secretion throughout the ovine estrous cycle.
In order to define the patterns of gonadotropin-releasing hormone (GnRH) secretion during the estrous cycle of the sheep we sampled hypophysial portal blood from conscious animals on day 1 of the… Expand
Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat.
Synthetic GH secretagogues (GHSs) act via a receptor (GHS-R) distinct from that for GH-releasing hormone (GHRH). We have studied the hypothalamic expression and regulation of this receptor by in situ… Expand
Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6.
The effects of growth hormone-releasing peptide-6 (GHRP-6) on peripheral plasma concentrations of growth hormone (GH) and hypophysial portal plasma concentrations of growth hormone-releasing hormone… Expand
Hypothalamic STAT Proteins: Regulation of Somatostatin Neurones by Growth Hormone Via STAT5b
- E. Bennett, L. McGuinness, +4 authors S. Luckman
- Biology, Medicine
- Journal of neuroendocrinology
- 1 March 2005
Signal transducers and activators of transcription (STATs) are a family of transcription factors linked to class I cytokine receptors. In the present study, we investigated whether their distribution… Expand
Isolation of Chlamydia trachomatis from amniotic fluid
- G. Thomas, J. Jones, A. Sbarra, C. Cetrulo, D. Reisner
- Obstetrics and gynecology
- 1 September 1990
A 26-year-old white woman had premature rupture of membranes at 35 weeks' gestation. Cervical specimens initially demonstrated group B streptococci and Chlamydia trachomatis. Amniocentesis was… Expand
NNZ-2566: A Gly–Pro–Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke
- M. J. Bickerdike, G. Thomas, D. C. Batchelor, E. Sirimanne, P. Gluckman
- Journal of the Neurological Sciences
- 15 March 2009
The N-terminal cleavage product of human insulin-like growth factor-1 (IGF-1) in the brain is the tripeptide molecule Glypromate (Gly-Pro-Glu). Glypromate has demonstrated neuroprotective effects in… Expand