Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
Migraine as a risk factor for subclinical brain lesions.
These population-based findings suggest that some patients with migraine with and without aura are at increased risk for subclinical lesions in certain brain areas.
Analysis of shared heritability in common disorders of the brain
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Migraine pathophysiology: lessons from mouse models and human genetics
Genome-wide meta-analysis identifies new susceptibility loci for migraine
A meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine and 95,425 population-matched controls, identifies 12 loci associated with migraine susceptibility and suggests potential functional candidate genes at four loci.
Erratum: Detection and interpretation of shared genetic influences on 42 human traits
44 independent single-nucleotide polymorphisms significantly associated with migraine risk were identified that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to the authors' knowledge is the first to be identified on chromosome X.
C-terminal truncations in human 3′-5′ DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy
Heterozygous C-terminal frameshift mutations in TREX1 retain exonuclease activity but lose normal perinuclear localization, which has implications for the maintenance of vascular integrity in the degenerative cerebral microangiopathies leading to stroke and dementias.
The prevalence and characteristics of migraine in a population-based cohort
The prevalence of migraine was significantly higher in women and not associated with socioeconomic status and the coexistence of migraine with and without aura occurs frequently and has implications for future studies on the genetics of migraine.
Novel mutations in the Na+, K+‐ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions
- Kaate R. J. Vanmolkot, E. Kors, A. M. van den Maagdenberg
- Medicine, BiologyAnnals of Neurology
- 1 September 2003
Novel missense mutations in the ATP1A2 Na+,K+‐ATPase pump gene on chromosome 1q23 in two families with FHM are described, which involve dysfunction of ion transportation and epilepsy is part of its phenotypic spectrum.
Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1
To the knowledge, the data establish rs1835740 as the first genetic risk factor for migraine.