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Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism.
Delta9-THC and heroin exert similar effects on mesolimbic dopamine transmission through a common mu1 opioid receptor mechanism located in the ventral mesencephalic tegmentum.
Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.
- F. Pontieri, G. Tanda, G. Di Chiara
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 19 December 1995
In vivo neurochemical evidence is provided for a functional compartmentation within the nucleus accumbens and for a preferential effect of psychostimulants and morphine in the shell of the nucleus Accumbens at doses known to sustain intravenous drug self-administration.
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs
It is reported that intravenous nicotine in the rat, at doses known to maintain self-administration, stimulates local energy metabolism, as measured by 2-deoxyglucose autoradiography, and dopamine transmission, as estimated by brain microdialysis, in the shell of the nucleus accumbens.
Blockade of the Noradrenaline Carrier Increases Extracellular Dopamine Concentrations in the Prefrontal Cortex: Evidence that Dopamine Is Taken up In Vivo by Noradrenergic Terminals
It is suggested that reuptake into NA terminals is an important mechanism by which DA is cleared from the extracellular space in a NA‐rich area such as the prefrontal cortex and may play a role in the therapeutic effects of these drugs.
Self-administration behavior is maintained by the psychoactive ingredient of marijuana in squirrel monkeys
Monkeys show persistent intravenous self-administration behavior by monkeys for doses of THC lower than doses used in previous studies, but comparable to doses in marijuana smoke inhaled by humans.
Fatty acid amide hydrolase (FAAH) inhibition enhances memory acquisition through activation of PPAR-alpha nuclear receptors.
Using a passive-avoidance task in rats, it is found that memory acquisition was enhanced by the FAAH inhibitor URB597 or by the PPAR-alpha agonist WY14643, and these enhancements were blocked by thePPAR- alpha antagonist MK886.
Differential Effects of Caffeine on Dopamine and Acetylcholine Transmission in Brain Areas of Drug-naive and Caffeine-pretreated Rats
Cannabinoids: reward, dependence, and underlying neurochemical mechanisms—a review of recent preclinical data
The goal of this review is to examine the various animal models currently available that are being used to facilitate understanding of the rewarding and dependence-producing actions of cannabinoids, which are central to their abuse liability, and of the neurochemical mechanisms that may underlie these actions.
Increase of extracellular dopamine in the prefrontal cortex: a trait of drugs with antidepressant potential?
The possibility that the property of stimulating dopamine transmission in the prefrontal cortex has a role in the antidepressant properties of these drugs is raised.
The Endogenous Cannabinoid Anandamide Produces δ-9-Tetrahydrocannabinol-Like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by…
- M. Solinas, G. Tanda, S. Goldberg
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 April 2007
Anandamide has THC-like discriminative and neurochemical effects that are enhanced after treatment with a FAAH inhibitor but not aftertreatment with transport inhibitors, suggesting brain area specificity for FAAH versus transport/FAAH inactivation of anandamide.