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- Publications
- Influence
Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.
- Weijia Xie, G. Tanabe, +6 authors O. Muraoka
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 March 2011
Two hitherto missing members of sulfonium salts family in Salacia genus plants as a new class of α-glucosidase inhibitors, neoponkoranol (7) and neosalaprinol (8), were isolated from the water… Expand
Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens[S]
- J. Ridlon, S. Ikegawa, +10 authors P. Hylemon
- Biology, Medicine
- Journal of Lipid Research
- 1 September 2013
Clostridium scindens American Type Culture Collection 35704 is capable of converting primary bile acids to toxic secondary bile acids, as well as converting glucocorticoids to androgens by side-chain… Expand
Synthesis and elucidation of absolute stereochemistry of salaprinol, another thiosugar sulfonium sulfate from the ayurvedic traditional medicine Salacia prinoides
- G. Tanabe, Mika Sakano, T. Minematsu, Hisashi Matusda, M. Yoshikawa, O. Muraoka
- Chemistry
- 20 October 2008
Abstract Synthesis and elucidation of absolute stereochemistry of salaprinol (3) isolated from the root and stems of Salacia prinoides, which has been used for the treatment of diabetes in India, Sri… Expand
Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity
- T. Morikawa, N. Kitagawa, +7 authors O. Muraoka
- Chemistry, Medicine
- Molecules
- 1 July 2016
A quantitative analytical method for five aporphine alkaloids, nuciferine (1), nornuciferine (2), N-methylasimilobine (3), asimilobine (4), and pronuciferine (5), and five benzylisoquinoline… Expand
Salaprinol and Ponkoranol with Thiosugar Sulfonium Sulfate Structure from Salacia prinoides and α-Glucosidase Inhibitory Activity of Ponkoranol and Kotalanol Desulfate.
- M. Yoshikawa, F. Xu, +4 authors O. Muraoka
- Chemistry
- 14 October 2008
Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata.
- M. Yoshikawa, T. Morikawa, H. Matsuda, G. Tanabe, O. Muraoka
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 May 2002
A most potent alpha-glucosidase inhibitor named salacinol has been isolated from an antidiabetic Ayurvedic traditional medicine, Salacia reticulata WIGHT, through bioassay-guided separation. The… Expand
On the structure of the bioactive constituent from ayurvedic medicine Salacia reticulata: revision of the literature
- O. Muraoka, Weijia Xie, G. Tanabe, Mumen F. A. Amer, T. Minematsu, M. Yoshikawa
- Chemistry
- 15 December 2008
The reported structure of a potent α-glucosidase inhibitor 7 isolated recently from ayurvedic medicine Salacia reticulata was found incorrect, and the compound was proved to be de-O-sulfated… Expand
Antidiabetogenic constituents from Salacia species
- H. Mastuda, M. Yoshikawa, T. Morikawa, G. Tanabe, O. Muraoka
- Chemistry
- 2005
- 29
- 1
Potential antitumor-promoting diterpenes from the cones of Pinus luchuensis.
- T. Minami, S. Wada, H. Tokuda, G. Tanabe, O. Muraoka, R. Tanaka
- Biology, Medicine
- Journal of natural products
- 15 October 2002
A new nor-labdane-type diterpene, 15-nor-labda-8(17),12E-dien-13,19-dienoic acid (1), along with five known diterpenes, 15-nor-14-oxolabda-8(17),12E-dien-19-oic acid (2), trans-communic acid (3),… Expand
Role of the side chain stereochemistry in the α-glucosidase inhibitory activity of kotalanol, a potent natural α-glucosidase inhibitor.
- Weijia Xie, G. Tanabe, +5 authors O. Muraoka
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 April 2011
Synthesis and evaluation of four diastereomers (9a, 9b, 9c and 9d) of kotalanol, a potent α-glucosidase inhibitor isolated from an Ayurvedic medicinal plant Salacia species, are described.… Expand