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Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2.

TLDR
Mangiferin suppressed the progression and incidence of CIA in DBA1/J mice and markedly inhibited not only developing but also clinically evident CIA, suggesting that mangiferin has potential clinical applications for the treatment of rheumatoid arthritis.
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Salacinol, potent antidiabetic principle with unique thiosugar sulfonium sulfate structure from the Ayurvedic traditional medicine Salacia reticulata in Sri Lanka and India

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Alkaloid constituents from flower buds and leaves of sacred lotus (Nelumbo nucifera, Nymphaeaceae) with melanogenesis inhibitory activity in B16 melanoma cells.

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Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens[S]

TLDR
Using RNA-Seq technology, a cortisol-inducible (∼1,000-fold) operon (desABCD) encoding at least one enzyme involved in anaerobic side-chain cleavage is identified andylogenetic analysis suggests this operon is rare in nature and the desC gene evolved from a gene encoding threonine dehydrogenase.
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Isolation, structure identification and SAR studies on thiosugar sulfonium salts, neosalaprinol and neoponkoranol, as potent α-glucosidase inhibitors.

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Quantitative Determination of Alkaloids in Lotus Flower (Flower Buds of Nelumbo nucifera) and Their Melanogenesis Inhibitory Activity

A quantitative analytical method for five aporphine alkaloids, nuciferine (1), nornuciferine (2), N-methylasimilobine (3), asimilobine (4), and pronuciferine (5), and five benzylisoquinoline…
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Synthesis and elucidation of absolute stereochemistry of salaprinol, another thiosugar sulfonium sulfate from the ayurvedic traditional medicine Salacia prinoides

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Salaprinol and Ponkoranol with Thiosugar Sulfonium Sulfate Structure from Salacia prinoides and α-Glucosidase Inhibitory Activity of Ponkoranol and Kotalanol Desulfate.

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Synthesis and Elucidation of Absolute Stereochemistry of Salaprinol, Another Thiosugar Sulfonium Sulfate from the Ayurvedic Traditional Medicine Salacia prinoides.

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Absolute stereostructure of potent alpha-glucosidase inhibitor, Salacinol, with unique thiosugar sulfonium sulfate inner salt structure from Salacia reticulata.

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