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Efficacy and Safety of the Biosimilar Infliximab CT-P13 Treatment in Inflammatory Bowel Diseases: A Prospective, Multicentre, Nationwide Cohort.
BACKGROUND AND AIMS Biosimilar infliximab CT-P13 is approved for all indications of the originator product in Europe. Prospective data on its efficacy, safety, and immunogenicity in inflammatoryExpand
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High affinity interaction of mibefradil with voltage‐gated calcium and sodium channels
Mibefradil is a novel Ca2+ antagonist which blocks both high‐voltage activated and low voltage‐activated Ca2+ channels. Although L‐type Ca2+ channel block was demonstrated in functional experimentsExpand
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Nuclear Targeting of Chlorin e6 Enhances Its Photosensitizing Activity*
Although photosensitizers, molecules that produce active oxygen species upon activation by visible light, are being extensively used in photodynamic therapy to treat cancer and other clinicalExpand
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Visual impairment and blindness in Hungary
The aim of this study was to estimate the prevalence and causes of blindness, severe visual impairment (SVI), moderate visual impairment (MVI), and early visual impairment (EVI) and its causes in anExpand
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Met5‐enkephalin‐Arg 6‐Phe7, an endogenous neuropeptide, binds to multiple opioid and nonopioid sites in rat brain
Receptor binding properties of the naturally occurring opioid heptapeptide MERF were studied in rat brain membrane preparations using tritium‐labeled derivative of the peptide with 40 Ci/mmolExpand
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Pain Inhibition by Endomorphins
Abstract: Spinal analgesic effects of endomorphin‐1 and endomorphin‐2 were studied during acute, inflammatory, and neuropathic pain in rats chronically implanted with intrathecal cannulas.Expand
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Liquid chromatographic study of the enzymatic degradation of endomorphins, with identification by electrospray ionization mass spectrometry.
The recently discovered native endomorphins play an important role in opioid analgesia, but their metabolic fate in the organism remains relatively little known. This paper describes the applicationExpand
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Suppression of melanoma cell proliferation by histidine decarboxylase specific antisense oligonucleotides.
Histidine decarboxylase (HDC) is expressed by the cells of melanoma, in which the histamine content tends to be relatively high. This study shows that elevated expression of HDC was found by westernExpand
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Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies.
Evidence from behavioral studies suggests that the process of weaning activates the development of a delta-opioid receptor subtype. We now report the influence of weaning on the development of deltaExpand
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Nociceptin binding sites in frog (Rana esculenta) brain membranes.
The recently discovered natural heptadecapeptide nociceptin (orphanin FQ) shares some homology with the opioid peptides but it binds to a distinct receptor type, termed nociceptin receptor. ThisExpand
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