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Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties
TLDR
Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5‐lipoxygenase in the micromolar concentration range and exhibits antioxidant properties. Expand
Cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) selectivity of COX inhibitors.
TLDR
Among COX inhibitors, celecoxib and ML-3000 (licofelone) inhibited 5-LOX in human neutrophils at micromolar ranges and it was shown that inhibition of COX pathways did not increase the transformation of arachidonic acid by the 5- LOX pathway. Expand
Respiratory burst inhibition in human neutrophils by ultra‐low doses of [D‐Ala2]methionine enkephalinamide
TLDR
An ultra‐low dose of opioid peptide [D‐Ala2]methionine enkephalinamide (DAMEA) is found to exert an inhibitory effect on the production of reactive oxygen species (respiratory burst) in human neutrophils, which indicates that the DAMEA action is at least partially mediated by opioid receptors. Expand
Cholesterol and its anionic derivatives inhibit 5‐lipoxygenase activation in polymorphonuclear leukocytes and MonoMac6 cells
TLDR
It is shown that cellular LT production is regulated by sulfated cholesterol, and a possible regulatory role of sulfotransferases/sulfatases in 5‐LO product synthesis is highlighted. Expand
Scanning electron microscopy study of neutrophil membrane tubulovesicular extensions (cytonemes) and their role in anchoring, aggregation and phagocytosis. The effect of nitric oxide.
TLDR
Using scanning electron microscopy, it is demonstrated that tubulovesicular extensions of neutrophils executed long-range adhesion and binding objects for phagocytosis, such as serum-opsonized zymosan particles and erythrocytes. Expand
Activation of NF‐κB transcription factor in human neutrophils by sulphatides and L‐selectin cross‐linking
TLDR
It is found that sulphatide activated transcription factor NF‐κB in human neutrophils in a concentration‐dependent manner whereas non‐sulphated galactocerebroside did not demonstrate such an effect. Expand
Neutrophils as a source of branched-chain, aromatic and positively charged free amino acids
TLDR
Plasma of patients with diabetes is characterized by an increased content of branched-chain and aromatic amino acids and a reduced ratio of arginine/ornithine compared to healthy human plasma, and the secretion of neutrophils can contribute to this shift in the amino acid content. Expand
Synthetic CpG oligonucleotides as potential modulators of neutrophil survival in PAMP‐associated inhibition of apoptosis
TLDR
The sensitivity of PMNLs to ODN2006, a modulator of apoptosis, increased significantly under conditions of infectious inflammation, and Inactivated S. typhimurium proved to be suitable for simulating inflammatory conditions in vitro. Expand
Magic Peptide: Unique Properties of the LRR11 Peptide in the Activation of Leukotriene Synthesis in Human Neutrophils
TLDR
It is found for the first time that the combination of the magic peptide LRR11 from the leucine-rich repeat of TLR9 with the CpG-ODNs modulates the uptake and signaling from ODNs, in particular, dramatically stimulates 5-LOX pathway. Expand
Purification of prostaglandin H synthetase and a fluorometric assay for its activity.
TLDR
It has been shown that homovanillic acid may be used as the electron donor and that in the presence of HVA the enzyme has an activity of approximately 40 microM/min/mg. Expand
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