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Bioprospecting for Microbial Endophytes and Their Natural Products
Endophytic microorganisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic, which may produce a plethora of substances of potential use to modern medicine, agriculture, and industry.
Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew.
Taxomyces andreanae, a fungal endophyte, was isolated from the phloem (inner bark) of the Pacific yew, Taxus brevifolia, and taxol was identified by mass spectrometry, chromatography, and reactivity with monoclonal antibodies specific for taxol.
Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana.
- G. Strobel, X. Yang, J. Sears, R. Kramer, R. Sidhu, W. M. Hess
- Biology, MedicineMicrobiology
- 1 February 1996
Pestalotiopsis microspora was isolated from the inner bark of a small limb of Himalayan yew, and was shown to produce taxol in mycelial culture, and spectroscopic and chromatographic comparisons with authentic taxol were identified.
Natural products from endophytic microorganisms.
- G. Strobel, Bryn Daisy, U. Castillo, J. Harper
- Biology, MedicineJournal of natural products
- 6 February 2004
The prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great and other applications in industry and agriculture may also be discovered among the novel products produced by endophytic microbes.
Endophytes as sources of bioactive products.
- G. Strobel
- Biology, MedicineMicrobes and infection
- 1 May 2003
Volatile antimicrobials from Muscodor albus, a novel endophytic fungus.
The ecological implications and potential practical benefits of the 'mycofumigation' effects of M. albus are described and the most effective class of inhibitory compounds was the esters, of which 1-butanol, 3-methyl-, acetate was the most active biologically.
Taxol from fungal endophytes and the issue of biodiversity
- G. Strobel, W. Hess, E. Ford, RS Sidhu, X. Yang
- BiologyJournal of Industrial Microbiology
- 1 November 1996
Information on the presence of taxol among disparate fungal genera is presented, and these observations are used as an additional argument to support efforts to study fungal endophytes and preserve their associated host plants.
Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans.
Munumbicins A, B, C and D are newly described antibiotics with a wide spectrum of activity against many human as well as plant pathogenic fungi and bacteria, and a Plasmodium sp. These compounds were…
Muscodor albus and its biological promise
- G. Strobel
- Biology, MedicineJournal of Industrial Microbiology and…
- 21 February 2006
Artificial mixtures of the VOCs nicely mimicked the biological effects of the fungal V OCs when tested against a wide range of fungal and bacterial pathogens.
New endophytic isolates of Muscodor albus, a volatile-antibiotic-producing fungus.
Interestingly, none of the new isolates of M. albus had a culture morphology that was identical to the original isolate, nevertheless each possessed hyphal characteristics that resembled that isolate.