• Publications
  • Influence
Isoflurane Differentially Affects Neurogenesis and Long-term Neurocognitive Function in 60-day-old and 7-day-old Rats
TLDR
Isoflurane improved spatial reference memory of P60 rats long-term, but it caused a delayed-onset, progressive, persistent hippocampal deficit in P7 rats in fear conditioning and spatialreference memory tasks. Expand
Effect of Hypercarbia and Isoflurane on Brain Cell Death and Neurocognitive Dysfunction in 7-day-old Rats
TLDR
Isoflurane-induced brain cell death may be partly caused by hypercarbia, and the inconsistencies between cell death and neurocognitive outcome suggest that additional or alternative mechanisms may mediate anesthesia-induced long-term neuroc cognitive dysfunction. Expand
Delayed Environmental Enrichment Reverses Sevoflurane-induced Memory Impairment in Rats
TLDR
Delayed environmental enrichment rescued the sevoflurane-induced impairment in short-term memory and generally improved many tested aspects of cognitive function, both in sev ofluran-treated and control animals. Expand
Isoflurane Inhibits Growth but Does Not Cause Cell Death in Hippocampal Neural Precursor Cells Grown in Culture
TLDR
The authors conclude that isoflurane does not cause cell death, but it does act directly on neural progenitor cells independently of effects on the surrounding brain to decrease proliferation and increase neuronal fate selection. Expand
Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.
TLDR
mounting evidence from preclinical studies reveals general anaesthetics to be powerful modulators of neuronal development and function, which could contribute to detrimental behavioural outcomes, however, definitive clinical data remain elusive. Expand
Neurotoxicity of Anesthetic Drugs in the Developing Brain
TLDR
This review gives an overview of some of the mechanisms that have been proposed for anesthesia-induced cognitive decline and discusses possible treatment options, and discusses early results of comparative animal studies of anesthetic neurotoxicity. Expand
&ggr;-Aminobutyric Acid-A Receptors Contribute to Isoflurane Neuroprotection in Organotypic Hippocampal Cultures
TLDR
It is likely that neuroprotection produced by isoflurane is multifactorial and includes actions at both GABAA and glutamate receptors and possibly other mechanisms. Expand
Isoflurane Does Not Affect Brain Cell Death, Hippocampal Neurogenesis, or Long-term Neurocognitive Outcome in Aged Rats
TLDR
In aged rats, isoflurane does not affect brain cell death, hippocampal neurogenesis, or long-term neurocognitive outcome. Expand
Neurogenic and Humoral Vasoconstriction in Acute Pulmonary Thromboembolism
TLDR
A better understanding of events leading to increased pulmonary artery pressure (PAP) and RVF is required to develop additional treatments and to further reduce mortality in this challenging patient population. Expand
Distinct long-term neurocognitive outcomes after equipotent sevoflurane or isoflurane anaesthesia in immature rats.
TLDR
Isoflurane might be more detrimental than sevoflurane in very young animals and cause a deficit in short-term memory, and sev of lurane-treated animals had a deficits in both short- term and early long- term memory. Expand
...
1
2
3
4
...