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Drug targeting to tumors: principles, pitfalls and (pre-) clinical progress.
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle.
TLDR
The results suggest achievement of two levels of targeting: tumor tissue selective delivery via the nanoparticle ligand and gene pathway selectivity via the siRNA oligonucleotide, opening the door for better targeted therapeutics with both tissue and gene selectivity, also to improve targeted therapies with less than ideal therapeutic targets.
Endosomal escape pathways for delivery of biologicals.
Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes.
TLDR
Evidence was found that preferential glucocorticoid delivery to the inflamed joint was the key factor explaining the observed strong therapeutic benefit obtained with the liposomal preparation, while other possible mechanisms, such as splenic accumulation or prolonged release of prednisolone in the circulation, were excluded.
Tumour-targeted nanomedicines: principles and practice
TLDR
The most important targeting systems and strategies, and discuss recent advances and future directions in the development of tumour-targeted nanomedicines, are summarized.
A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice.
TLDR
A new model for xenogeneic GVHD (X-GVHD) by intravenous transfer of huPBMCs into RAG2-/- gammac-/- mice is developed, with a high human T-cell chimerism associated with a consistent development of XGVHD within 14 to 28 days and a total mortality rate of 85% shorter than 2 months.
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
TLDR
The combination of chelation or incorporation of imaging moieties and pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release will further improve specificity and efficacy of micelle-based drug delivery.
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