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Lower urinary tract dysfunction in Parkinson's disease: changes relate to age and not disease.
Bladder capacity was reduced in both men and women with Parkinson's disease in comparison with patients of similar to that measured in patients without neurological disease and no evidence of obstruction was found. Expand
Asymmetry of substantia nigra neuronal loss in Parkinson's disease and its relevance to the mechanism of levodopa related motor fluctuations.
A pathological study of 21 patients with Parkinson's disease of asymmetrical onset revealed significant asymmetry of degeneration of the substantia nigra with greater neuronal loss contralateral to the initially affected body side, and suggested that striatal dopamine storage is not an important determinant of duration of clinical response to levodopa doses. Expand
Low‐dose L‐dopa therapy in Parkinson's disease
After 6 years of treatment, only one-third of patients were better, and drug-related complications were common, and there was no evidence that long-term results were markedly improved with low-dose regimens. Expand
Comparison of motor response to apomorphine and levodopa in Parkinson's disease.
Clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease. Expand
Anal sphincter dysfunction in Parkinson's disease.
Dysfunction of the striated anal sphincter musculature may be a significant cause of constipation in some parkinsonian patients, occurring as part of the generalized extrapyramidal motor disorder. Expand
Increased prevalence of undernutrition in Parkinson's disease and its relationship to clinical disease parameters
The reduction in anthropometric indices was most marked for skin fold thickness and least for arm muscle circumference (related to lean body mass); therefore the weight loss seen in Parkinson's disease is primarily due to fat loss rather than muscle loss. Expand
Motor response to levodopa in patients with parkinsonian motor fluctuations: a follow-up study over three years.
A short response time to the levodopa test dose was not an invariable finding in patients with severe fluctuations, whereas all had large response amplitudes and high "off" phase disability scores. Expand
Tetrahydroisoquinoline Alkaloids: in vivo Metabolites of L-Dopa in Man
Tetrahydroisoquinoline alkaloids have been unequivocally demonstrated in vivo for the first time in parkinsonian patients on L-dopa treatment. Their biosynthesis may have a profound bearing on howExpand
Deprenyl is metabolized to methamphetamine and amphetamine in man.
Myopathy, osteomalacia and hyperparathyroidism.