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Predominant role for C5b-9 in renal ischemia/reperfusion injury.
TLDR
The membrane attack complex of complement (in which C5 and C6 participate) may account for the effect of complement on mouse renal I/R injury and is a potential target for prevention of I-R injury in this model. Expand
Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease.
TLDR
Findings strongly point to a role for the lectin pathway of complement in glomerular complement activation in IgAN and suggest a contribution for both MBL and L-ficolin in the progression of the disease. Expand
Human IgA Activates the Complement System Via the Mannan-Binding Lectin Pathway1
TLDR
MBL binding to IgA results in complement activation, which is proposed to lead to a synergistic action of MBL and IgA in antimicrobial defense, and may explain glomerular complement deposition in IgA nephropathy. Expand
Complement Induction in Spinal Cord Microglia Results in Anaphylatoxin C5a-Mediated Pain Hypersensitivity
TLDR
It is concluded that induction of the complement cascade in spinal cord microglia after peripheral nerve injury contributes to neuropathic pain through the release and action of the C5a anaphylatoxin peptide. Expand
Myocardial infarction and apoptosis after myocardial ischemia and reperfusion: role of the terminal complement components and inhibition by anti-C5 therapy.
TLDR
Anti-C5 therapy in the setting of MI/R significantly inhibits cell apoptosis, necrosis, and PMN infiltration in the rat despite C3 deposition. Expand
Limitation of reperfusion injury by a monoclonal antibody to C5a during myocardial infarction in pigs.
TLDR
Myocardial infarction-reperfusion is associated with activation of the alternative complement pathway and C5a in the propagation of ischemia cardiac damage during reperfusion, and a MAb to C4a that inhibits neutrophil cytotoxic activity, but neither the membrane attack complex nor myocardial neutrophils accumulation, decreases infarct size in pigs. Expand
Neutrophil-derived Glutamate Regulates Vascular Endothelial Barrier Function*
TLDR
It is concluded that activated human PMNs release glutamate and that endothelial expression of group I or III mGluRs function to decrease human brain endothelial VASP phosphorylation and barrier function. Expand
The Lectin Pathway of Complement Activation Is a Critical Component of the Innate Immune Response to Pneumococcal Infection
TLDR
It is shown that mouse ficolin A, human L-ficolin, and collectin 11 in both species, but not mannan-binding lectin (MBL), are the pattern recognition molecules that drive lectin pathway activation on the surface of S. pneumoniae, and that pneumococcal opsonisation via the Lectin pathway can proceed in the absence of C4. Expand
Hydrogen sulfide therapy attenuates the inflammatory response in a porcine model of myocardial ischemia/reperfusion injury.
TLDR
Therapeutic sulfide provides protection in response to ischemia/reperfusion injury, improving myocardial function, reducing infarct size, and improving coronary microvascular reactivity, potentially through its anti-inflammatory properties. Expand
Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1.
TLDR
Investigation of whether oxidative stress increases human umbilical vein endothelial cell cytokeratin 1 (CK1) expression and activates the lectin complement pathway and whether MBL binding to endothelial cytokeratins may mediate LCP activation after oxidative stress suggests that MBLbinding to endothelium may Mediate L CP activation after antioxidant stress. Expand
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