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ACUTE RETINAL DAMAGE AFTER USING A TOXIC PERFLUORO-OCTANE FOR VITREO-RETINAL SURGERY
Purpose: To describe a series of retinal acute toxicity cases with severe visual loss after intraocular use of a toxic perfluoro-octane (PFO). The clinical presentation is described, and the likely
Lentiviral vectors transcriptionally targeted to hematopoietic cells by WASP gene proximal promoter sequences
TLDR
Lentiviral vectors incorporating proximal promoter sequences from the WASP gene confer hematopoietic-specific, and physiological protein expression and transduction of WASp-deficient cells with WW conferred a selective growth advantage in vitro.
Comparison between direct contact and extract exposure methods for PFO cytotoxicity evaluation
TLDR
A new cytotoxicity test method for volatile substances detected toxic PFO lots that corresponded to the lots producing clinical blindness, which previous methods failed to detect.
Elastin-like recombinamers as substrates for retinal pigment epithelial cell growth.
TLDR
Results should be extended to further studies with fresh human RPE cells and in vivo studies to determine whether this ELR-RGD matrix could be used as a Bruch's membrane prosthesis and carrier for transplantation of R PE cells in patients suffering with AMD.
A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells
TLDR
The neuroretinas cocultured with RPE cells maintained better tissue structure and cellular organization, displayed better preservation of photoreceptors containing rhodopsin, lower levels of glial fibrillary acidic protein immunoexpression, and preservation of cellular retinaldehyde binding protein both markers of reactive gliosis.
Adalimumab (tumor necrosis factor-blocker) reduces the expression of glial fibrillary acidic protein immunoreactivity increased by exogenous tumor necrosis factor alpha in an organotypic culture of
TLDR
In cultured porcine neuroretina, spontaneous reactive gliosis and retinal disorganization were exacerbated by exogenous TNF α, and inhibiting TNFα may represent a novel approach to controlling retinal fibrosis observed in some human diseases.
Current focus of stem cell application in retinal repair.
TLDR
Recent research achievements of the applications of these three types of stem cells as well as clinical trials currently based on them are reviewed, with a focus on iPSCs.
Chitosan Feasibility to Retain Retinal Stem Cell Phenotype and Slow Proliferation for Retinal Transplantation
TLDR
RSCs express proteins belonging to epithelial, glial, and neural cells, confirming that they need further stimulus to reach a final destination of differentiation that could be provided in in vivo condition and chitosan membrane can be used as a cell carrier so that slow proliferating RSCs can migrate and integrate into retina.
An exopolysaccharide produced by the novel halophilic bacterium Halomonas stenophila strain B100 selectively induces apoptosis in human T leukaemia cells
TLDR
The newly discovered B100S is the first bacterial EPS that has been demonstrated to exert a potent and selective pro-apoptotic effect on T leukaemia cells, and it is proposed that the search for new antineoplastic drugs should include the screening of other bacterial EPSs, particularly those isolated from halophiles.
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