G. Spraggon

Publications225
h-index41
Citations5,960
Highly Influential Citations226
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Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin
TLDR
The structure of a core fragment (fragment D) from human fibrinogen has now been determined to 2.9 Å resolution and the 86K three-chained structure consists of a coiled-coil region and two homologous globular entities oriented at approximately 130 degrees to each other.
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A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase.
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Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
TLDR
The structure helps explain the reported unique peptide substrate specificity and the importance of phosphorylation of the first A-loop Tyr1278 for kinase activity and NPM-ALK transforming potential and the availability of a three-dimensional structure for ALK will facilitate future structure-function and rational drug design efforts targeting this receptor tyrosine kinase.
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Crystal structure of human Pus10, a novel pseudouridine synthase.
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Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline
TLDR
The design and implementation of a high-throughput structural genomics pipeline and its application to the proteome of the thermophilic bacterium Thermotoga maritima is described and successfully cloned and attempted expression of 1,376 of the predicted 1,877 genes.
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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
TLDR
A selective inhibitor of the kinetoplastid proteasome (GNF6702) with unprecedented in vivo efficacy, which cleared parasites from mice in all three models of infection, underscores the possibility of developing a single class of drugs for these neglected diseases.
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FdeC, a Novel Broadly Conserved Escherichia coli Adhesin Eliciting Protection against Urinary Tract Infections
TLDR
The structural and functional properties of a recently reported protective antigen, named FdeC, are described and its putative role during extraintestinal pathogenic E. coli infection is elucidated by using both in vitro and in vivo infection models.
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Shotgun crystallization strategy for structural genomics: an optimized two-tiered crystallization screen against the Thermotoga maritima proteome.
TLDR
This data shows that the two-tiered strategy employed here is extremely successful for predicting which proteins will readily crystallize, as greater than 99% of the proteins identified as having a propensity to crystallize under non-optimal native conditions did so again as selenomethionine derivatives during the focused crystallization trials.
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Crystal structure of fragment double-D from human fibrin with two different bound ligands.
TLDR
Factor XIII-cross-linked fragment D (double-D) from human fibrin was crystallized in the presence of two different peptide ligands and the X-ray structure shows for the first time that the beta-chain knob does indeed bind to a homologous hole on thebeta-chain.
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Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197
TLDR
The crystal structures of the full-length nucleotide-free CRM197 and ofCRM197 in complex with the NAD hydrolysis product nicotinamide (NCA) are determined and show for the first time that the overall fold of CRM 197 and DT are nearly identical and that the striking functional difference between the two proteins can be explained by a flexible active-site loop that covers the NAD binding pocket.
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