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Investigations on the binding properties of the nootropic agent pyroglutamic acid.
The two stereoisomers of pyroglutamic acid (PCA), a nootropic or cognition-enhancing agent, and classic reference compounds were investigated for their ability to interact with 27 neurotransmitterExpand
Phosphatidylserine increases acetylcholine release from cortical slices in aged rats
It is proposed that the chronic phosphatidylserine treatment may reduce the age-induced decrease in acetylcholine release by acting on the stimulus-secretion coupling mechanism. Expand
Oxiracetam prevents electroshock-induced decrease in brain acetylcholine and amnesia.
The hypothesis that oxiracetam may prevent the disruption of the conditioned response by acting on cortical and hippocampal cholinergic mechanisms is supported. Expand
Interactions between oxiracetam, aniracetam and scopolamine on behavior and brain acetylcholine
In conclusion, oxiracetam and anir acetam exert a stimulatory effect on specific central cholinergic pathways, however, a direct relationship between cognition-enhancing properties and Cholinergic activation needs further confirmation. Expand
Nootropic drugs and brain cholinergic mechanisms
  • G. Pepeu, G. Spignoli
  • Psychology, Medicine
  • Progress in Neuro-Psychopharmacology and…
  • 31 December 1989
The information available is not yet sufficient to define at which steps of the cognitive process the action on cholinergic system plays a role and which are the influences of the changes in Cholinergic function on other neurochemical mechanisms of learning and memory. Expand
Biphasic effect of methylxanthines on acetylcholine release from electrically‐stimulated brain slices
The results indicate that methylxanthines exert both stimulatory and inhibitory effects on ACh release by acting on adenosine receptors, and may enhance the electrically‐evoked A choline release by antagonizing the effect of endogenousAdenosine on inhibitory adenosines receptors. Expand
Effect of Oxiracetam and Piracetam on Central Cholinergic Mechanisms and Active‐Avoidance Acquisition
It is indicated that oxiracetam enhances the activity of the septohippocampal cholinergic pathways, and to a lesser extent, of the corticalCholinergic network. Expand
The relationship between the behavioral effects of cognition-enhancing drugs and brain acetylcholine. Nootropic drugs and brain acetylcholine.
When scopolamineinduced disruption of behavior is prevented or reduced, the scopolamininduced decrease in ACh level, particularly in the hippocampus, is also reduced, suggesting a relationship between the cognition-enhancing effects of oxiracetam and its effects on hippocampal and cortical cholinergic mechanisms. Expand