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Role of cardiolipin alterations in mitochondrial dysfunction and disease.
Cardiolipin (CL) is a structurally unique dimeric phospholipid localized in the inner mitochondrial membrane where it is required for optimal mitochondrial function. In addition to its role inExpand
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Mitochondrial calcium transport: mechanisms and functions.
Ca(2+)transport across the mitochondrial inner membrane is facilitated by transporters having four distinct sets of characteristics as well as through the Ca(2+)-induced mitochondrial permeabilityExpand
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Mitochondrial Calcium Uptake from Physiological-type Pulses of Calcium
A controversy in the field of bioenergetics has been whether mitochondria are capable of sequestering enough Ca2+ from cytosolic Ca2+ pulses to raise their intramitochondrial free Ca2+ levelExpand
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Arrangement of the Respiratory Chain Complexes in Saccharomyces cerevisiae Supercomplex III2IV2 Revealed by Single Particle Cryo-Electron Microscopy*
Background: Organization of respiratory chains as “respirasome” superstructures is established. Results: Three-dimensional cryo-EM analysis of the yeast supercomplex III2IV2 identified theExpand
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Loss of cardiac tetralinoleoyl cardiolipin in human and experimental heart failure Published, JLR Papers in Press, April 10, 2007.
The mitochondrial phospholipid cardiolipin is required for optimal mitochondrial respiration. In this study, cardiolipin molecular species and cytochrome oxidase (COx) activity were studied inExpand
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Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart.
The effect of endurance training on the resistance of the heart to left ventricular (LV) functional deficit and infarction after a transient regional ischemia and subsequent reperfusion was examined.Expand
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Cardiolipin Remodeling in the Heart
Cardiolipin (CL) is a mitochondrial phospholipid that fundamentally contributes to the function of many proteins in the inner mitochondrial membrane, where it is actively involved in the integrityExpand
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Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis.
Apoptosis has been identified recently as a component of many cardiac pathologies. However, the potential triggers of programmed cell death in the heart and the involvement of specific metabolicExpand
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A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis.
After cardiac ischemia, long-chain fatty acids, such as palmitate, increase in plasma and heart. Palmitate has previously been shown to cause apoptosis in cardiac myocytes. Cultured neonatal ratExpand
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The rapid mode of calcium uptake into heart mitochondria (RaM): comparison to RaM in liver mitochondria.
A mechanism of Ca(2+) uptake, capable of sequestering significant amounts of Ca(2+) from cytosolic Ca(2+) pulses, has previously been identified in liver mitochondria. This mechanism, the Rapid ModeExpand
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