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&NA; Cell lines which exhibit epithelial morphology with surface microvilli and inclusion bodies characteristic of type 2 pneumocytes have been derived from normal adult mouse lung by a simpleExpand
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Isolation Culture, and Transplantation of Rat Hepatocytic Precursor (Stem-like) Cells
Abstract From a review of past studies and the report of new studies from our laboratory, this article provides strong evidence to show that WB-F344 (WB) rat liver epithelial cells are stem-likeExpand
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Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors.
Age of host and transplantation-site microenvironment influence the tumorigenic potential of neoplastically transformed liver epithelial cells. Tumorigenic BAG2-GN6TF rat liver epithelial cellsExpand
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Development of dexamethasone‐inducible tyrosine aminotransferase activity in WB‐F344 rat liver epithelial stemlike cells cultured in the presence of sodium butyrate
Sodium butyrate acts as a differentiation‐promoting agent for a wide variety of cell types, including some tumor cell lines. In this study, we examined the effects of sodium butyrate (SB) on theExpand
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Regulation of the differentiation of diploid and some aneuploid rat liver epithelial (stemlike) cells by the hepatic microenvironment.
Following intrahepatic transplantation in adult syngeneic Fischer 344 rats, diploid cultured rat liver epithelial cells (WB-F344), modified to carry the Escherichia coli beta-galactosidase reporterExpand
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Characterization of a neoplastic epithelial cell strain derived by dexamethasone treatment of cultured normal mouse type 2 pneumocytes
The epithelial cell strain NAL1A cultured from normal adult mouse lung has been transformed by culturing in dexamethasone into an invasive neoplastic cell strain. The criteria for neoplasticExpand
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Overexpression of c-K-ras, c-N-ras and transforming growth factor beta co-segregate with tumorigenicity in morphologically transformed C3H 10T1/2 cell lines.
Morphologic transformation and tumorigenicity are separate cellular phenotypes in transformed 10T1/2 cells. We have investigated the levels of expression of genes for c-myc, c-H-ras, c-K-ras,Expand
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Short‐Term Diethylnitrosamine‐Induced Oval Cell Responses In Three Strains Of Mice
&NA; The oval cells of the liver have been identified as target cells of chemical carcinogens during rat hepatocarcinogenesis and are believed to act as liver stem cells. In this study mice (strainsExpand
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Decreased 8N3-[γ-32P]GTP photolabeling of Gsα in tumorigenic lung epithelial cell lines: Association with decreased hormone responsiveness and loss of contact-inhibited growth☆
Abstract The 45-kDa α subunit of the signal transducing G s protein complex, which stimulates receptor-coupled adenylate cyclase, incorporated less of the photoaffinity probe, 8N 3 -[γ- 32 P]GTP, inExpand
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Malignant epithelial cell strains cultured from BALB/c mouse lung adenoma.
  • G. Smith, J. Bentel
  • Biology, Medicine
  • Cell biology international reports
  • 1 February 1987
Urethane-induced lung adenomas from adult BALB/c mice were explanted onto a plastic substratum and cultured in order to establish the epithelial cell strain NUL1. The cell strain exhibited aExpand
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