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Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
TLDR
The different catalytic properties and the different subnuclear localization patterns shown by the human homologues indicate that hABH2 and hABh3 have distinct roles in the cellular response to alkylation damage, which is important for establishing RNA repair as a potentially important defence mechanism in living cells.
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DNA glycosylases in the base excision repair of DNA.
TLDR
Structural data and sequence comparisons have identified common features among many of the DNA glycosylases, which initiate the base excision repair pathway, and a conserved helix-hairpin-helix motif and an invariant Asp residue are found in the active sites of more than 20 monofunctional and bifunctional DNA gly cosylases.
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Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil‐DNA glycosylase with DNA
TLDR
UDG binds to AP sites more tightly and more rapidly than to uracil‐containing DNA, and thus may protect cells sterically from AP site toxicity, and AP site binding may couple damage‐specific and damage‐general steps of BER without requiring direct protein–protein interactions.
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Human uracil–DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination
TLDR
It is shown that recessive mutations of the gene encoding uracil–DNA glycosylase (UNG) are associated with profound impairment in CSR at a DNA precleavage step and with a partial disturbance of the SHM pattern in three patients with hyper-IgM syndrome.
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Alkylation damage in DNA and RNA--repair mechanisms and medical significance.
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A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA
TLDR
The structure of one of the engineered human UDG mutants represents the first structure of any eukaryotic DNA repair enzyme in complex with its damaged, target DNA and reveals the basis for the enzyme-assisted nucleotide flipping by this critical DNA-repair enzyme.
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The interacting pathways for prevention and repair of oxidative DNA damage.
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Uracil in DNA – occurrence, consequences and repair
TLDR
A role for UNG2, together with activation induced deaminase (AID) which generates uracil, has been demonstrated in immunoglobulin diversification and studies are now underway to examine whether mice deficient in Ung develop lymphoproliferative malignancies and have a different life span.
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Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA
View on Elsevier
Post‐replicative base excision repair in replication foci
TLDR
This work reports that the major nuclear uraci‐DNA glycosylase (UNG2) increases in S phase, during which it co‐localizes with incorporated BrdUrd in replication foci and demonstrates rapid post‐replicative removal of incorporated uracil by UNG2.
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