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XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.
Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug activity/specificity determination, and basic metabolic research requires new data preprocessing approaches to correlateExpand
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Reliability of Spike Timing in Neocortical Neurons
screen of the microscope. Between 150 to 300 nerve fibers were analyzed per cross section. 13. C. F. Eldridge, M. Bartlett, R. P. Bunge, P. M. Wood, J. Cell Biol. 105, 1023 (1987); C. F. Eldridge, M.Expand
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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
Although it has long been recognized that the enteric community of bacteria that inhabit the human distal intestinal track broadly impacts human health, the biochemical details that underlie theseExpand
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Generation of induced pluripotent stem cells using recombinant proteins.
Document S1. Supplemental Experimental Procedures, One Table, and Two FiguresxDownload (1.25 MB ) Document S1. Supplemental Experimental Procedures, One Table, and Two FiguresMovie S1. BeatingExpand
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XCMS Online: a web-based platform to process untargeted metabolomic data.
Recently, interest in untargeted metabolomics has become prevalent in the general scientific community among an increasing number of investigators. The majority of these investigators, however, doExpand
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METLIN: A Metabolite Mass Spectral Database
Endogenous metabolites have gained increasing interest over the past 5 years largely for their implications in diagnostic and pharmaceutical biomarker discovery. METLIN (http://metlin.scripps.edu), aExpand
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Innovation: Metabolomics: the apogee of the omics trilogy
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands ofExpand
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An accelerated workflow for untargeted metabolomics using the METLIN database
Metabolites, typically recognized as small molecules that are involved in cellular reactions, provide a functional signature of phenotype that is complimentary to the upstream biochemical informationExpand
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Desorption–ionization mass spectrometry on porous silicon
Desorption mass spectrometry has undergone significant improvements since the original experiments were performed more than 90 years ago. The most dramatic change occurred in the early1980s with theExpand
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The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells (iPSCs) remains largely unexplored. Here we report, using an untargeted metabolomicsExpand
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