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XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification.
- C. A. Smith, E. Want, Grace O'Maille, R. Abagyan, G. Siuzdak
- Chemistry, Medicine
- Analytical chemistry
- 7 January 2006
Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug activity/specificity determination, and basic metabolic research requires new data preprocessing approaches to correlate… Expand
Reliability of Spike Timing in Neocortical Neurons
screen of the microscope. Between 150 to 300 nerve fibers were analyzed per cross section. 13. C. F. Eldridge, M. Bartlett, R. P. Bunge, P. M. Wood, J. Cell Biol. 105, 1023 (1987); C. F. Eldridge, M.… Expand
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Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites
- W. R. Wikoff, Andrew T Anfora, +4 authors G. Siuzdak
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 10 March 2009
Although it has long been recognized that the enteric community of bacteria that inhabit the human distal intestinal track broadly impacts human health, the biochemical details that underlie these… Expand
Generation of induced pluripotent stem cells using recombinant proteins.
Document S1. Supplemental Experimental Procedures, One Table, and Two FiguresxDownload (1.25 MB ) Document S1. Supplemental Experimental Procedures, One Table, and Two FiguresMovie S1. Beating… Expand
XCMS Online: a web-based platform to process untargeted metabolomic data.
- Ralf Tautenhahn, G. Patti, Duane Rinehart, G. Siuzdak
- Medicine, Chemistry
- Analytical chemistry
- 10 May 2012
Recently, interest in untargeted metabolomics has become prevalent in the general scientific community among an increasing number of investigators. The majority of these investigators, however, do… Expand
METLIN: A Metabolite Mass Spectral Database
- C. A. Smith, Grace O' Maille, +6 authors G. Siuzdak
- Chemistry, Medicine
- Therapeutic drug monitoring
- 1 December 2005
Endogenous metabolites have gained increasing interest over the past 5 years largely for their implications in diagnostic and pharmaceutical biomarker discovery. METLIN (http://metlin.scripps.edu), a… Expand
Innovation: Metabolomics: the apogee of the omics trilogy
- G. Patti, Ó. Yanes, G. Siuzdak
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 April 2012
Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of… Expand
An accelerated workflow for untargeted metabolomics using the METLIN database
- Ralf Tautenhahn, Kevin Cho, Winnie Uritboonthai, Zhengjiang Zhu, G. Patti, G. Siuzdak
- Medicine, Biology
- Nature Biotechnology
- 10 September 2012
Metabolites, typically recognized as small molecules that are involved in cellular reactions, provide a functional signature of phenotype that is complimentary to the upstream biochemical information… Expand
Desorption–ionization mass spectrometry on porous silicon
- Jing Wei, J. Buriak, G. Siuzdak
- Medicine, Chemistry
- Nature
- 20 May 1999
Desorption mass spectrometry has undergone significant improvements since the original experiments were performed more than 90 years ago. The most dramatic change occurred in the early1980s with the… Expand
The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming
- A. D. Panopoulos, Ó. Yanes, +12 authors J. Belmonte
- Medicine, Biology
- Cell Research
- 2012
Metabolism is vital to every aspect of cell function, yet the metabolome of induced pluripotent stem cells (iPSCs) remains largely unexplored. Here we report, using an untargeted metabolomics… Expand