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- Publications
- Influence
A Comparison of Assay Performance Measures in Screening Assays: Signal Window, Z' Factor, and Assay Variability Ratio
- P. Iversen, B. Eastwood, G. Sittampalam, K. Cox
- Mathematics, Medicine
- Journal of biomolecular screening
- 1 April 2006
In this article, the authors compare the assay performance measures, signalwindow, Z' factor, and assay variability ratio. They examine their mathematical formulae for similarities and differences,… Expand
Assay Guidance Manual
- G. Sittampalam, N. Coussens, +16 authors J. R. Weidner
- Chemistry
- 2004
Setting up drug discovery and development programs in academic, non-profit and other life science research companies requires careful planning. This chapter contains guidelines to develop therapeutic… Expand
- 194
- 9
- PDF
HTS Assay Validation
- P. Iversen, B. Beck, +9 authors G. Sittampalam
- Materials Science
- 1 October 2012
- 96
- 6
Stem Cells in Drug Discovery, Tissue Engineering, and Regenerative Medicine: Emerging Opportunities and Challenges
- V. S. Nirmalanandhan, G. Sittampalam
- Biology, Medicine
- Journal of biomolecular screening
- 1 August 2009
Stem cells, irrespective of their origin, have emerged as valuable reagents or tools in human health in the past 2 decades. Initially, a research tool to study fundamental aspects of developmental… Expand
Design of Signal Windows in High Throughput Screening Assays for Drug Discovery
- G. Sittampalam, P. Iversen, +5 authors M. Lister
- Computer Science
- 1 April 1997
TLDR
Activity of anticancer agents in a three-dimensional cell culture model.
- V. S. Nirmalanandhan, A. Duren, P. Hendricks, G. Vielhauer, G. Sittampalam
- Medicine
- Assay and drug development technologies
- 25 October 2010
Cell-monolayer-based assays for chemotherapeutic drug discovery have proven to be highly artificial compared with physiological systems. The objective of this study was to culture cancer cells in a… Expand
A Multicenter Pilot Study Examining the Role of Circulating Tumor Cells as a Blood-Based Tumor Marker in Patients with Extensive Small-Cell Lung Cancer
- C. Huang, J. Wick, +9 authors P. V. Van Veldhuizen
- Medicine
- Front. Oncol.
- 14 October 2014
Background: Small-cell lung cancer (SCLC), a variant of lung cancer marked by early metastases, accounts for 13% of all lung cancers diagnosed in US. Despite high response rates to treatment, it is… Expand
Basics of Assay Equipment and Instrumentation for High Throughput Screening
- E. Jones, S. Michael, G. Sittampalam
- Computer Science
- 2 April 2016
- 15
- 2
Small-Molecule Screens: A Gateway to Cancer Therapeutic Agents with Case Studies of Food and Drug Administration–Approved Drugs
- N. Coussens, J. Braisted, Tyler Peryea, G. Sittampalam, A. Simeonov, M. Hall
- Medicine
- Pharmacological Reviews
- 1 October 2017
High-throughput screening (HTS) of small-molecule libraries accelerates the discovery of chemical leads to serve as starting points for probe or therapeutic development. With this approach, thousands… Expand
A high-throughput screening assay for determining cellular levels of total tau protein.
- Seameen J Dehdashti, W. Zheng, +6 authors S. Prusiner
- Biology, Medicine
- Current Alzheimer research
- 31 August 2013
The microtubule-associated protein (MAP) tau has been implicated in the pathology of numerous neurodegenerative diseases. In the past decade, the hyperphosphorylated and aggregated states of tau… Expand