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Deficiency of a β-arrestin-2 signal complex contributes to insulin resistance
Insulin resistance, a hallmark of type 2 diabetes, is a defect of insulin in stimulating insulin receptor signalling, which has become one of the most serious public health threats. Upon stimulationExpand
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Cross‐linking CD40 on B cells preferentially induces stress‐activated protein kinases rather than mitogen‐activated protein kinases.
The B cell‐associated surface molecule CD40 plays a key role in T cell‐dependent B cell maturation, as individuals with defects in either CD40 or its ligand are impaired in immunoglobulin isotypeExpand
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p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes.
We have investigated the activation of the p38 MAPK pathway in response to CD40 engagement in multiple B cell lines and in human tonsillar B cells to define the role of p38 MAPK in proliferation,Expand
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FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers
The forkhead box transcription factor A2 (FOXA2) is an important regulator in animal development and body homeostasis. However, whether FOXA2 is involved in transforming growth factor β1Expand
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Signal transducer and activator of transcription 3 (STAT3) regulates adipocyte differentiation via peroxisome‐proliferator‐activated receptor γ (PPARγ)
Background information. STAT3 (signal transducer and activator of transcription 3) is an important transcription factor involved in many biological events, including apoptosis, tumorigenesis,Expand
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Histone deacetylase 1 is required for transforming growth factor-beta1-induced epithelial-mesenchymal transition.
UNLABELLED Epithelial-mesenchymal transition (EMT) has been implicated in embryonic development, fibrosis, and tumor metastasis. Histone deacetylases (HDACs) also play important roles in the controlExpand
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Gastrodin stimulates anticancer immune response and represses transplanted H22 hepatic ascitic tumor cell growth: Involvement of NF-κB signaling activation in CD4+ T cells.
Gastrodia elata Blume (G. elata) is a famous restorative food in East Asia. It can be used as an auxiliary reagent in hepatocellular carcinoma (HCC) treatment. Previous studies unveiled that G. elataExpand
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Antidiabetic effect of total saponins from Entada phaseoloides (L.) Merr. in type 2 diabetic rats.
ETHNOPHARMACOLOGICAL RELEVANCE The seed of Entada phaseoloides (L.) Merr. (Entada phaseoloides) has been long used as an effective herb for the treatment of Diabetes mellitus by Dai people, one ofExpand
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Antidiabetic Effect of Methanolic Extract from Berberis julianae Schneid. via Activation of AMP-Activated Protein Kinase in Type 2 Diabetic Mice
We have investigated the antidiabetic effect and mechanism of methanolic extract of Berberis julianae Schneid. (BJSME) in STZ induced Type 2 diabetes mellitus mice. T2DM mice were induced by high fatExpand
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The CD40-inducible Bcl-2 family member A1 protects B cells from antigen receptor-mediated apoptosis.
CD40 activation is necessary for thymus-dependent humoral immune responses and rescuing both phenotypically immature WEHI-231 B lymphoma cells from B cell antigen receptor-induced cell death andExpand
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