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Neuroepithelial progenitors undergo LGN-dependent planar divisions to maintain self-renewability during mammalian neurogenesis
During mammalian development, neuroepithelial cells function as mitotic progenitors, which self-renew and generate neurons. Although spindle orientation is important for such polarized cells to… Expand
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
The gut microbiota affects nutrient acquisition and energy regulation of the host, and can influence the development of obesity, insulin resistance, and diabetes. During feeding, gut microbes produce… Expand
Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice
- S. Nakagawa, Takao Naganuma, G. Shioi, T. Hirose
- Biology, Medicine
- The Journal of cell biology
- 4 April 2011
Mouse NEAT1 is required for paraspeckle formation in a subset of cells but is not essential for animal health and viability.
ChIP‐Atlas: a data‐mining suite powered by full integration of public ChIP‐seq data
We have fully integrated public chromatin chromatin immunoprecipitation sequencing (ChIP‐seq) and DNase‐seq data (n > 70,000) derived from six representative model organisms (human, mouse, rat, fruit… Expand
Establishment of conditional reporter mouse lines at ROSA26 locus for live cell imaging
A series of conditional reporter mouse lines were established in which specific organelles were labeled with fluorescent proteins. Subcellular localization and intensity of 28 fluorescent… Expand
Conserved expression of mouse Six1 in the pre-placodal region (PPR) and identification of an enhancer for the rostral PPR.
All cranial sensory organs and sensory neurons of vertebrates develop from cranial placodes. In chick, amphibians and zebrafish, all placodes originate from a common precursor domain, the… Expand
Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes.
During meiosis, homologous chromosome (homolog) pairing is promoted by several layers of regulation that include dynamic chromosome movement and meiotic recombination. However, the way in which… Expand
Caenorhabditis elegans PlexinA, PLX-1, interacts with transmembrane semaphorins and regulates epidermal morphogenesis.
The plexin family transmembrane proteins are putative receptors for semaphorins, which are implicated in the morphogenesis of animal embryos, including axonal guidance. We have generated and… Expand
Regulation of Six1 expression by evolutionarily conserved enhancers in tetrapods.
- Shigeru Sato, K. Ikeda, G. Shioi, K. Nakao, H. Yajima, K. Kawakami
- Medicine, Biology
- Developmental biology
- 1 August 2012
The Six1 homeobox gene plays critical roles in vertebrate organogenesis. Mice deficient for Six1 show severe defects in organs such as skeletal muscle, kidney, thymus, sensory organs and ganglia… Expand
Calcilytic Ameliorates Abnormalities of Mutant Calcium‐Sensing Receptor (CaSR) Knock‐In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH)
- B. Dong, I. Endo, +8 authors T. Matsumoto
- Medicine, Biology
- Journal of bone and mineral research : the…
- 1 November 2015
Activating mutations of calcium‐sensing receptor (CaSR) cause autosomal dominant hypocalcemia (ADH). ADH patients develop hypocalcemia, hyperphosphatemia, and hypercalciuria, similar to the clinical… Expand