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Structure and Function of AvtR, a Novel Transcriptional Regulator from a Hyperthermophilic Archaeal Lipothrixvirus
Systematic evolution of ligands by exponential enrichment (SELEX) experiments combined with systematic mutational and computational analysis of the predicted site revealed 8 potential AvtR targets in the AFV6 genome, and the complex role of AvTR in the transcriptional regulation of viral genes was established.
Genetic Characterization and Cloning of Genes for Chlortetracycline Resistance in Streptomyces Aureofaciens Strains
Coordinated transcription of resistance and biosynthesis genes has been demonstrated in Streptomyces rimosus strains and it is shown that these genes are related to high level of antibiotic activity.
[Cloning of grisin resistance gene gsr and the study of its functioning in Streptomyces griseus Kr. strain].
- G. Sezonov, G. Kriugel', E. A. Kudriashova, L. Kolibaba, N. D. Lomovskaia
- BiologyAntibiotiki i khimioterapiia = Antibiotics and…
- 1 December 1990
Introduction of a gsr gene within the multicopy plasmid pIJ699 into S. griseus 212, a highly productive strain synthesiing the antibiotic, led to an increase in its resistance and productivity.
[Chromosomal determinant of Streptomyces hygroscopicus with positive influence on resistance to bialaphos controlled by the bar gene].
It was shown that the cloned determinant had a positive action on bar gene transcription correlating with a significant increase in the activity of N-acetyltransferase in the mycelium of the transformant pVG B21.
[Expression of cloned bialaphos resistance gene (bar) in Streptomyces strains].
- G. Sezonov, V. Tabakov, E. A. Kudriashova
- Biology, EngineeringAntibiotiki i khimioterapiia = Antibiotics and…
The object of the study was a strain of Streptomyces hygroscopicus producing bialaphos, an antibiotic used as a herbicide, which is promising and ecologically safe, and confirmed the data on different regulation of bar and pat resistance genes.
[Molecular genetic studies of the DNA promotor regions in Bacillus thuringiensis subsp. galleriae 69-6. I. Structural and functional analysis].
Three recombinant plasmids pPBT9, pPBT10 and pPBT74 carrying promoter-containing regions of DNA of Bacillus thuringiensis which are responsible for the expression of the promoterless tet gene, were…
Biosynthesis of antibiotics in streptomycetes
The most significant advance resulted from the studies on genetic control of biosynthesis pathways of antibiotics, with a number of important findings indicating linkage of these genes to each other and to the genes for resistance to autogeneous antibiotics.
[Enterobacterial gene expression of antibiotic resistance under the control of Bacillus thuringiensis regulatory signals in gram-negative and gram-positive bacteria].
Bireplicon pSTS228 plasmid containing its own enterobacterial promoter of tet gene was not able to express tetracycline resistance in Bac.
[Determinants of resistance to chlortetracycline and other antibiotics in chlortetracycline-producing strain of Streptomyces aureofaciens].
Data are presented on resistance of Streptomyces aureofaciens strain TB-633 FU--the producer of chlortetracycline (CTC) to autogenous antibiotics and a number of other antibiotics. It is demonstrated…
[Herbicide antibiotic bialaphos: the stages and genetic control of its biosynthesis; growth of bialaphos-resistant plants].