• Publications
  • Influence
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder.
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci thatExpand
  • 92
  • 6
  • PDF
The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample
The diacylglycerol kinase eta gene and bipolar disorder: a replication study in a Sardinian sample
  • 32
  • 5
  • PDF
Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study
Background Lithium remains a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, noExpand
  • 154
  • 3
  • PDF
The International Consortium on Lithium Genetics (ConLiGen): An Initiative by the NIMH and IGSLI to Study the Genetic Basis of Response to Lithium Treatment
For more than half a decade, lithium has been successfully used to treat bipolar disorder. Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and prophylacticExpand
  • 111
  • 3
  • PDF
Age at onset in Sardinian bipolar I patients: evidence for three subgroups.
OBJECTIVE We studied age at onset (AAO) in order to assess the presence of different subgroups in a homogeneous genetic population, such as the Sardinian population. METHODS Admixture analysis wasExpand
  • 59
  • 3
Association study in a Sardinian sample between bipolar disorder and the nuclear receptor REV-ERBalpha gene, a critical component of the circadian clock system.
OBJECTIVE The aim of our study was to investigate the association between REV-ERBalpha gene (NR1D1) single nucleotide polymorphisms (SNPs) and bipolar disorder (BP) in a case-control sample ofExpand
  • 63
  • 3
Adverse drug reactions: role of pharmacogenomics.
Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality. The majority of ADRs can be considered common disorders with considerable clinical variability (clinical phenotype)Expand
  • 71
  • 3
Haplotype association study between DRD1 gene and bipolar type I affective disorder in two samples from Canada and Sardinia
Based on the dopaminergic hypothesis, the dopamine D1 receptor gene (DRD1) is considered to be a good candidate gene involved in the susceptibility of bipolar disorder (BP). Genetic associationExpand
  • 21
  • 3
Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder.
AIMS Bipolar disorder (BD) is a lifelong psychiatric illness characterized by manic and depressive episodes affecting 1-5% of the general population. Among mood-stabilizing treatments, lithiumExpand
  • 70
  • 2
A48G polymorphism in the D1 receptor genes associated with bipolar I disorder
Several lines of evidence point to a role for dopamine in mood disorders and, in particular, in bipolar disorders. In line with a considerable amount of evidence, the dopamine D1 receptor gene (DRD1)Expand
  • 52
  • 2