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The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man.
Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivoExpand
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Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies.
Monoclonal antibodies of the OKT series were used to identify T lymphocytes (OKT3+) and their inducer (OKT4+) and suppressor-cytotoxic (OKT8+) subsets in the peripheral blood mononuclear cells (PBMC)Expand
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Characterization of immunoregulatory T lymphocytes in insulin-dependent diabetic children by means of monoclonal antibodies.
Monoclonal antibodies of the OKT series were used to identify total T lymphocytes (OKT3+) and their helper (OKT4+) and suppressor-cytotoxic (OKT8+) and suppressor-cytotoxic (OKT8+) subsets in 34Expand
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Antithyroid antibodies underlying thyroid abnormalities and miscarriage or pregnancy induced hypertension
Objective To assess whether asymptomatic abnormalities, including thyroid auto‐antibodies, were associated with an abnormal miscarriage rate or a poor obstetric outcome.
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Modulation of immune response in aged humans through different administration modes of thymopentin
SummaryThymopentin, a synthetic pentapeptide corresponding to the active site of thymopoietin, has been shown to restore antibody production in old mice. A decrease in immune response can also beExpand
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Anti-cyclic citrullinated peptide antibodies: a comparison of different assays for the diagnosis of rheumatoid arthritis
Objectives: Anti-cyclic citrullinated peptide (anti-CCP) antibodies are highly specific markers of rheumatoid arthritis (RA). Considering the heterogeneity of the target antigens involved, and theExpand
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Evidence of autoantibodies to cell membrane associated DNA (cultured lymphocytes): a new specific marker for rapid identification of systemic lupus erythematosus
OBJECTIVE Autoantibodies to cell membrane associated DNA are described in systemic lupus erythematosus (SLE). The specificity of these antibodies differ from antibodies to nuclear DNA. METHODS UsingExpand
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In vitro influence of thymopentin on proliferative responses and phytohemagglutinin-induced interleukin 2 production in normal human lymphocyte cultures
SummaryPeripheral human blood lymphocytes from healthy blood donors were investigated in vitro to observe the influence of different doses of thymopentin on nonstimulated proliferation,Expand
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Immunomodulation with thymopentin in humans.
The effect of thymopentin administered i.v. or s.c. on the levels of circulating specific IgM and IgG KLH (key-hole limpet haemocyanine) antibodies and non-specific immunoglobulins were measured atExpand
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Cranial magnetic resonance imaging in eclampsia.
Although the precise neuropathologic basis for eclamptic convulsions remains unclear, intracranial hemorrhage is frequently associated with fatal cases. Magnetic resonance imaging (MRI) is a recentlyExpand
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