• Publications
  • Influence
Negative regulation of antigen receptor‐mediated signaling by constitutive asociation of CD5 with the SHP‐1 protein tyrosine phosphatase in B‐1 B cells
CD5, a membrane‐associated glycoprotein, has been shown to negatively regulate antigen receptor‐mediated growth responses in peritoneal B lymphocytes, thymocytes and mature T cells. TheExpand
  • 119
  • 9
HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes.
The TAR sequence at the 5'-termini of all HIV-1 mRNA species forms a stable structure that is responsible for both transcriptional and translational regulation of HIV-1. Previously we and othersExpand
  • 137
  • 7
Antibody responses in melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2.
We initiated a clinical trial for patients with advanced malignant melanoma treated with an anti-idiotype antibody that mimics the disialoganglioside GD2. We report the clinical and immune responsesExpand
  • 92
  • 3
  • PDF
Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: Involvement of macrophage inflammatory protein‐1α and monocyte chemoattractant protein‐1
Target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (ORNs), infiltration of macrophages, and proliferation of progenitor cells, leading toExpand
  • 47
  • 3
Ground-level concentration of nitrogen oxides (NOx) at some traffic intersection points in Calcutta
Abstract Results from a year long programme of measuring ground-level concentration of NOx at 19 important traffic intersection points within the city of Calcutta have been presented. FortnightlyExpand
  • 24
  • 2
Preclinical evaluation in nonhuman primates of murine monoclonal anti-idiotype antibody that mimics the disialoganglioside GD2.
The antiganglioside GD2 monoclonal antibody 14G2a (Ab1) served as an immunogen to generate the anti-idiotype (anti-Id) 1A7 (IgG1,kappa), which mimics GD2 both antigenically and biologically. Anti-IdExpand
  • 47
  • 1
  • PDF
Induction of IgG antibodies by an anti-idiotype antibody mimicking disialoganglioside GD2.
The anti-idiotype (Id) monoclonal antibody (mAb) 1A7 immunoglobulin G1 (IgG1, kappa), raised in syngeneic mice against the murine anti-ganglioside GD2 mAb 14G2a mimics a carbohydrate epitope on GD2Expand
  • 40
  • 1
Interferon-stimulated response element and NF kappa B sites cooperate to regulate double-stranded RNA-induced transcription of the IP-10 gene.
To understand the mechanisms involved in dsRNA-induced gene expression, we analyzed the poly(I/C)-induced transcription of the IFN-inducible chemokine gene IP-10 using the GRE cell line in which typeExpand
  • 53
  • 1
Defective CD19-dependent signaling in B-1a and B-1b B lymphocyte subpopulations.
Peritoneal and pleural cavities in mice and humans contain a unique population of B-lymphocytes called B-1 cells that are defective in B cell antigen receptor (BCR) signaling but have an increasedExpand
  • 31
  • 1
B and CD4+ T‐cell expression of TLR2 is critical for optimal induction of a T‐cell‐dependent humoral immune response to intact Streptococcus pneumoniae
TLR2−/− mice immunized with Streptococcus pneumoniae (Pn) elicit normal IgM, but defective CD4+ T‐cell‐dependent type 1 IgG isotype production, associated with a largely intact innate immuneExpand
  • 19
  • 1
  • PDF