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Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
TLDR
In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation. Expand
PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth
TLDR
The results suggest that the PTH/P THrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation. Expand
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.
TLDR
This genetic study has provided conclusive evidence demonstrating that GH and IGF1 promote postnatal growth by both independent and common functions, as the growth retardation of double Ghr/Igf1 nullizygotes is more severe than that observed with either class of single mutant. Expand
Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
TLDR
The sensitivity, specificity, and rapid turnaround time of this two-site IRMA should advance the laboratory evaluation of patients with disorders of calcium metabolism. Expand
The spectrum of bone disease in end-stage renal failure--an evolving disorder.
TLDR
It is suggested that peritoneal dialysis, perhaps by maintaining calcium at higher levels, may more effectively suppress the parathyroid gland. Expand
Na+/H+ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling
TLDR
NHERF-mediated assembly of PTH1R and phospholipase Cβ is a unique mechanism to regulate PTH signalling in cells and membranes of polarized cells that express NHERF, which may account for many tissue- and cell-specific actions of P TH/PTHrP and may also be relevant to signalling by many G-protein-coupled receptors. Expand
Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.
TLDR
It is demonstrated that PTHrP acts principally as a paracrine factor, which promotes elongation of endochondral bone by restraining or delaying the pace of chondrocytic development and terminal differentiation of growth-plate chondsrocytes. Expand
Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.
TLDR
The expression patterns of PTHrP and its receptor mRNAs during fetal development suggest P THrP's roles as a paracrine factor and its involvement in epithelial-mesenchymal(-like) interactions. Expand
Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues.
TLDR
Although, PTH/PTHrP receptor mRNAs are highly expressed in kidney and bone, classic PTH targets that are associated with calcium homeostasis, their wide tissue distribution suggests that PTH and/or PTHrp have other physiological roles, particularly in these other tissues. Expand
Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure.
TLDR
Data demonstrate the presence of hyperparathyroidism, normocalcemia, and 1,25-dihydroxyvitamin D3 deficiency in renal failure and are consistent with a role for 1-25-(OH)2D in the suppression of parathyroid activity through as yet unidentified mechanisms. Expand
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