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Regulation of Rate of Cartilage Differentiation by Indian Hedgehog and PTH-Related Protein
- A. Vortkamp, Kaechoong Lee, B. Lanske, G. Segre, H. Kronenberg, C. Tabin
- Biology, Medicine
- 2 August 1996
In vitro application of Hedgehog or P THrP protein to normal or PTHrP (−/−) limb explants demonstrated that PTHRP mediates the effects of Ihh through the formation of a negative feedback loop that modulates the rate of chondrocyte differentiation. Expand
PTH/PTHrP Receptor in Early Development and Indian Hedgehog--Regulated Bone Growth
The results suggest that the PTH/P THrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation. Expand
Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.
- F. Lupu, J. Terwilliger, K. Lee, G. Segre, A. Efstratiadis
- Biology, Medicine
- Developmental biology
This genetic study has provided conclusive evidence demonstrating that GH and IGF1 promote postnatal growth by both independent and common functions, as the growth retardation of double Ghr/Igf1 nullizygotes is more severe than that observed with either class of single mutant. Expand
Highly sensitive two-site immunoradiometric assay of parathyrin, and its clinical utility in evaluating patients with hypercalcemia.
The sensitivity, specificity, and rapid turnaround time of this two-site IRMA should advance the laboratory evaluation of patients with disorders of calcium metabolism. Expand
The spectrum of bone disease in end-stage renal failure--an evolving disorder.
It is suggested that peritoneal dialysis, perhaps by maintaining calcium at higher levels, may more effectively suppress the parathyroid gland. Expand
Na+/H+ exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling
NHERF-mediated assembly of PTH1R and phospholipase Cβ is a unique mechanism to regulate PTH signalling in cells and membranes of polarized cells that express NHERF, which may account for many tissue- and cell-specific actions of P TH/PTHrP and may also be relevant to signalling by many G-protein-coupled receptors. Expand
Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development.
It is demonstrated that PTHrP acts principally as a paracrine factor, which promotes elongation of endochondral bone by restraining or delaying the pace of chondrocytic development and terminal differentiation of growth-plate chondsrocytes. Expand
Expression of parathyroid hormone-related peptide and its receptor messenger ribonucleic acids during fetal development of rats.
The expression patterns of PTHrP and its receptor mRNAs during fetal development suggest P THrP's roles as a paracrine factor and its involvement in epithelial-mesenchymal(-like) interactions. Expand
Parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acids are widely distributed in rat tissues.
Although, PTH/PTHrP receptor mRNAs are highly expressed in kidney and bone, classic PTH targets that are associated with calcium homeostasis, their wide tissue distribution suggests that PTH and/or PTHrp have other physiological roles, particularly in these other tissues. Expand
Hyperparathyroidism and 1,25-dihydroxyvitamin D deficiency in mild, moderate, and severe renal failure.
- T. Pitts, B. Piraino, +4 authors J. Puschett
- Chemistry, Medicine
- The Journal of clinical endocrinology and…
- 1 November 1988
Data demonstrate the presence of hyperparathyroidism, normocalcemia, and 1,25-dihydroxyvitamin D3 deficiency in renal failure and are consistent with a role for 1-25-(OH)2D in the suppression of parathyroid activity through as yet unidentified mechanisms. Expand