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Hypothalamic KATP channels control hepatic glucose production
Obesity is the driving force behind the worldwide increase in the prevalence of type 2 diabetes mellitus. Hyperglycaemia is a hallmark of diabetes and is largely due to increased hepaticExpand
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Autophagy regulates adipose mass and differentiation in mice.
The relative balance between the quantity of white and brown adipose tissue can profoundly affect lipid storage and whole-body energy homeostasis. However, the mechanisms regulating the formation,Expand
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Obesity-associated improvements in metabolic profile through expansion of adipose tissue.
Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the inability toExpand
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Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms
Leucine, as an essential amino acid and activator of mTOR (mammalian target of rapamycin), promotes protein synthesis and suppresses protein catabolism. However, the effect of leucine on overallExpand
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Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Increased glucose production is a hallmark of type 2 diabetes and alterations in lipid metabolism have a causative role in its pathophysiology. Here we postulate that physiological increments inExpand
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Hypothalamic sensing of fatty acids
Selective regions of the brain, including the hypothalamus, are capable of gathering information on the body's nutritional status in order to implement appropriate behavioral and metabolic responsesExpand
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A brain-liver circuit regulates glucose homeostasis.
Increased glucose production (GP) is the major determinant of fasting hyperglycemia in diabetes mellitus. Previous studies suggested that lipid metabolism within specific hypothalamic nuclei is aExpand
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Hypothalamic nutrient sensing in the control of energy homeostasis
The hypothalamus is a center of convergence and integration of multiple nutrient-related signals. It can sense changes in circulating adiposity hormones, gastric hormones and nutrients, and receivesExpand
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A Gut Lipid Messenger Links Excess Dietary Fat to Dopamine Deficiency
Food as Reward Why does ice cream taste so good? High-fat foods activate a reward circuit in the brain involving dopamine, a neurotransmitter that regulates pleasure. Overconsumption of high-fatExpand
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The lipid messenger OEA links dietary fat intake to satiety.
The association between fat consumption and obesity underscores the need to identify physiological signals that control fat intake. Previous studies have shown that feeding stimulatesExpand
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