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The β Subunit Determines the Ligand Binding Properties of Synaptic Glycine Receptors
Inhibitory glycine receptors (GlyRs) regulate motor coordination and sensory signal processing in spinal cord and other brain regions. GlyRs are pentameric proteins composed of membrane-spanningExpand
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P2X1 and P2X3 receptors form stable trimers: a novel structural motif of ligand‐gated ion channels
P2X receptors are cation channels gated by extracellular ATP. The seven known P2X isoforms possess no sequence homology with other proteins. Here we studied the quaternary structure of P2X receptorsExpand
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Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor
P2X7 is the largest member of the P2X subfamily of purinergic receptors. A typical feature is the carboxyl tail, which allows formation of a large pore. Recently a naturally occurring truncated P2X7Expand
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The suramin analogue NF279 is a novel and potent antagonist selective for the P2X1 receptor
The suramin analogue 8,8'-(carbonylbis(imino-4, 1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)) bis(1,3,5-naphthalenetrisul fonic acid) (NF279) was analysed with respect to its potency and P2XExpand
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NF546 [4,4′-(Carbonylbis(imino-3,1-phenylene-carbonylimino-3,1-(4-methyl-phenylene)-carbonylimino))-bis(1,3-xylene-α,α′-diphosphonic Acid) Tetrasodium Salt] Is a Non-Nucleotide P2Y11 Agonist and
The G protein-coupled P2Y11 receptor is involved in immune system modulation. In-depth physiological evaluation is hampered, however, by a lack of selective and potent ligands. By screening a libraryExpand
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NF449: a subnanomolar potency antagonist at recombinant rat P2X1 receptors
Abstract. Antagonistic effects of the novel suramin analogue 4,4′,4′′,4′′′-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid (NF449) were studied onExpand
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Molecular characterization of human and bovine endothelin converting enzyme (ECE‐1)
A membrane‐bound protease activity that specifically converts Big endothelin‐1 has been purified from bovine endothelial cells (FBHE) The enzyme was cleaved with trypsin and the peptide sequencingExpand
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NF449, a novel picomolar potency antagonist at human P2X1 receptors.
The antagonistic effects of the novel suramin analogue 4,4',4",4"'-(carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid (NF449) were analyzed at homomericExpand
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Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes.
Of the three major classes of ligand-gated ion channels, nicotinic receptors and ionotropic glutamate receptors are known to be organized as pentamers and tetramers, respectively. The architecture ofExpand
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Ubiquitination Precedes Internalization and Proteolytic Cleavage of Plasma Membrane-bound Glycine Receptors*
The inhibitory glycine receptor (GlyR) in developing spinal neurones is internalized efficiently upon antagonist inhibition. Here we used surface labeling combined with affinity purification to showExpand
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