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A NOVEL ALZHEIMER DISEASE LOCUS LOCATED NEAR THE GENE ENCODING TAU PROTEIN
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International GenomicsExpand
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Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus
We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (totalExpand
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A novel long and unstable CAG/CTG trinucleotide repeat on chromosome 17q.
Using the direct identification of repeat expansion and cloning technique, we cloned a novel long CAG/CTG trinucleotide repeat on chromosome 17. Using radiation hybrid panels, the CAG/CTG repeat wasExpand
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Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
To follow-up loci discovered by the International Genomics of Alzheimer’s Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sampleExpand
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Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
Genetic variants in the sortilin-related receptor (SORL1) and the sortilin-related vacuolar protein sorting 10 (VPS10) domain-containing receptor 1 (SORCS1) are associated with increased risk ofExpand
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Meta-analysis of genetic association with diagnosed Alzheimer’s disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing
Late-onset Alzheimer’s disease (LOAD, onset age > 60 years) is the most prevalent dementia in the elderly1, and risk is partially driven by genetics2. Many of the loci responsible for this geneticExpand
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Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?
Murray and colleagues [1] reported the occurrence of pathologically-confirmed Alzheimer's disease (AD) in cases harbouring the TREM2 p.R47H variant only when APOE ε4 alleles were also present. TheyExpand
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Alzheimer's disease variant portal (ADVP): a catalog of genetic findings for Alzheimer's disease
Background: Alzheimer's disease (AD) genetic findings span progressively larger genome-wide association studies (GWASs) for various outcomes and populations. These genetic findings are obtained fromExpand
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Protein phosphatase 2A, complement component 4, and APOE genotype linked to Alzheimer disease using a systems biology approach
Background: Recent reports suggest that the rare apolipoprotein E (APOE) Christchurch mutation and {varepsilon}2 allele protect against Alzheimer disease (AD) pathology by reducing the burden of tauExpand
Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
There is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transferExpand